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Rebalance Oral Suspension

This product requires a veterinary prescription.
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A Chemical on the Prop 65 List
ReBalance® Oral Suspension
Product Information
ReBalance® Oral Suspension is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona in horses.
Generic Name
Pyrimethamine, Sulfadiazine
Brand Names
Drug Class
Product Flavoring
ReBalance® Oral Suspension is almond flavored.
PRN Pharmacal
Product Description & Form
ReBalance® Oral Suspension 1 Quart: suspension. (NDC 49427-0247-11)
  • Safe, easy and effective
  • Each ml contains 250 mg sulfadiazine and 12.5 mg pyrimethamine
  • Usual treatment regimen ranges from 90 to 270 days
Active Ingredients
Sulfadiazine sodium, Pyrimethamine
This product should be use as directed by your veterinarian. Shake well before each use.
Administer orally with a suitable dosing syringe at least one hour prior to feeding with hay or grain. Insert nozzle of syringe through the interdental space and deposit the dose on the back of the tongue by depressing the plunger. Syringes are sold separately.
Missed Doses
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.
Side Effects
ReBalance® Oral Suspension appears to be well tolerated; there are minimal side effects when used at appropriate doses but may include decreased appetite, loose stools, and mild colic. Other side effects may occur, report any side effects to your veterinarian.
Drug & Food Interactions
The following drugs can potentially interact with ReBalance® Oral Suspension: antacids, cyclosporine, thiazide diuretics, phenylbutazone, salicylates, probenecid, trimethoprim, and warfarin. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 
For use in horses only. The safety of ReBalance® Oral Suspension with concomitant therapies in horses has not been evaluated. Safe use in breeding, pregnancy, and lactation has not been evaluated.  Keep out of reach of children. 
Prior to treatment with Rebalance® Oral Suspension , EPM should be distinguished from the diseases that may cause ataxia in horses. Injuries or lameness may also complicate the evaluation of an animal with EPM. In most instances, ataxia due to EPM is asymmetrical and affects the front and/or the hind limbs. Treatment may cause generalized bone marrow suppression, anemia, leukopenia, neutropenia and thrombocytopenia. A complete blood count (CBC) should be performed monthly to monitor horses for development of these conditions. The administration of the drug may need to be discontinued and/or treatments for bone marrow suppression initiated. Worsened neurologic deficits (treatment crisis) may be observed during a period beginning with the first few days of treatment with ReBalance® Oral Suspension and ranging out to 5 weeks. This neurologic deficit exacerbation may be the result of an inflammatory reaction to the dying parasites in the CNS tissue.
Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; widespread hives and itching.
Adverse Reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer PRN Pharmacal at 850-476-9462 or Vetsource customer service at 877-738-4443.
Store at 68°F to 77°F in controlled room temperature, excursions permitted between 59°F to 86°F. Protect from freezing. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.
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Nutritional Info