Product details
Amantadine is an NMDA antagonist medication that is used as an add-on treatment in small animals to help control chronic pain.
- Used to help treat various types of chronic pain, including neuropathic and “wind-up” pain in dogs and cats
- Typically used in combination with other pain medications (e.g., gabapentin) to provide additional pain relief
- The FDA prohibits extra-label use of this drug in chickens, turkeys, and ducks.
- May be prescribed for other animal species; please consult your veterinarian.
- While this drug does not have an FDA-approved indication for all animal uses, it is commonly accepted for veterinarians to prescribe this medication for use in animals.
This product contains a chemical on the Prop 65 List.
*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.
Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs and Cats
Active ingredient(s)
Amantadine hydrochloride
Common brand names
Symmetrel
Drug class
NMDA antagonist
Product strength & size
This product may be available in multiple strengths and/or sizes; please select the appropriate option for your pet as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
Amantadine should be given orally as directed by your veterinarian.
The full benefit of this medication may not be observed until several weeks after starting. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.
This medication can be given with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.
Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
Possible side effects include (but may not be limited to): vomiting, diarrhea/loose stools, gas, and agitation. These effects are more likely to appear at the start of treatment (or when the dose is increased) and typically resolve over time.
Contact your veterinarian immediately if your pet displays any signs of overdose, including severe vomiting, dry mouth, excessive salivation, tremors, anxiety, or loss of coordination.
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
Do NOT use this medication in animals with severe kidney disease. The FDA prohibits extra-label use of this drug in chickens, turkeys, and ducks.
Use with caution in animals with liver or kidney disease, congestive heart failure, eczematoid dermatitis, seizure disorders, or untreated glaucoma.
This medication should be used with extreme caution (or avoided) in pregnant or nursing animals.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.
Drug and food interactions
The following drugs* may have potential interactions with this medication: acepromazine, antihistamines (e.g., diphenhydramine, hydroxyzine), hydrochlorothiazide, metoclopramide, potassium citrate, quinidine, selegiline, sulfa-/trimethoprim antibiotics, tramadol, and tricyclic antidepressants (e.g., amitriptyline, clomipramine).
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.
Last revised: 5/13/2025
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Description
Product detailsAmantadine is an NMDA antagonist medication that is used as an add-on treatment in small animals to help control chronic pain.- Used to help treat various types of chronic pain, including neuropathic and “wind-up” pain in dogs and cats
- Typically used in combination with other pain medications (e.g., gabapentin) to provide additional pain relief
- The FDA prohibits extra-label use of this drug in chickens, turkeys, and ducks.
- May be prescribed for other animal species; please consult your veterinarian.
- While this drug does not have an FDA-approved indication for all animal uses, it is commonly accepted for veterinarians to prescribe this medication for use in animals.
This product contains a chemical on the Prop 65 List.*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs and CatsActive ingredient(s)Amantadine hydrochlorideCommon brand namesSymmetrelDrug classNMDA antagonistProduct strength & sizeThis product may be available in multiple strengths and/or sizes; please select the appropriate option for your pet as recommended by your veterinarian.For current availability, please refer to the product selection above.UsageAmantadine should be given orally as directed by your veterinarian.The full benefit of this medication may not be observed until several weeks after starting. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.This medication can be given with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.Missed dosesAdminister the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.StorageStore in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsPossible side effects include (but may not be limited to): vomiting, diarrhea/loose stools, gas, and agitation. These effects are more likely to appear at the start of treatment (or when the dose is increased) and typically resolve over time.Contact your veterinarian immediately if your pet displays any signs of overdose, including severe vomiting, dry mouth, excessive salivation, tremors, anxiety, or loss of coordination.Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.PrecautionsDo NOT use this medication in animals with severe kidney disease. The FDA prohibits extra-label use of this drug in chickens, turkeys, and ducks.Use with caution in animals with liver or kidney disease, congestive heart failure, eczematoid dermatitis, seizure disorders, or untreated glaucoma.This medication should be used with extreme caution (or avoided) in pregnant or nursing animals.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.Drug and food interactionsThe following drugs* may have potential interactions with this medication: acepromazine, antihistamines (e.g., diphenhydramine, hydroxyzine), hydrochlorothiazide, metoclopramide, potassium citrate, quinidine, selegiline, sulfa-/trimethoprim antibiotics, tramadol, and tricyclic antidepressants (e.g., amitriptyline, clomipramine).*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.Last revised: 5/13/2025 -
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