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Apoquel Tablets
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Zoetis

Apoquel Tablets

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$46.50 - $310.00
UPC:
087219131084
Source:
Vetsource
Product Type:
Medication
Ship Class:
default
Subscription Recurring Discount:
5
Health Benefit:
Allergy
auto-order-discount:
8
auto-order:
true
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Product Information
Product details
Apoquel (oclacitinib tablet) for Dogs is indicated for the control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. This product is a coated tablet formulation. For the flavored chewable tablet formulation, please see Apoquel Chewable for Dogs.
  • #1 Prescribed Oral Medicine for Allergic Itch1: Apoquel is a revolutionary oral medicine for dogs with allergic itch. Apoquel can be used short-term or for long-term maintenance therapy2,3 in dogs 12 months of age and older.
  • Stops Allergic Itch at the Source4: Apoquel is not a steroid, antihistamine, or cyclosporine (a type of drug that reduces immune system activity). Apoquel is in a different category of medications. Unlike other medicines, Apoquel blocks allergic itch at the source. So, it works at the underlying cause of itch to provide relief fast.
  • Fast-Acting Allergy Itch Relief: If your dog is scratching, licking, or chewing like crazy, you want to provide fast, effective relief. Apoquel Tablets start relieving allergic itch within 4 hours5 and control it within 24 hours2. Apoquel has been prescribed to over 14 million dogs and counting.6
  • Can be used with many other medications3 including: nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines (such as rabies), and allergen-specific immunotherapy (allergy shots or drops). The use of Apoquel has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine.
  • Available in Three Strengths: Apoquel Tablets come in 3.6 mg, 5.4 mg, and 16 mg based on your dog’s body weight. Follow your veterinarian’s instructions for dosing as prescribed. You can administer to your dog orally once a day with or without food. Apoquel is now available in a pork-liver flavored chewable.

Apoquel Tablets control itching (pruritus) associated with allergic dermatitis and control atopic dermatitis in dogs at least 12 months of age. Apoquel has been prescribed for over 14 million dogs6 and is #1 in pet owner and vet satisfaction for oral medications for allergic itch in dogs*.7,8 It goes right to the source to help stop itching and relieve associated inflammation in affected canines providing relief in as little as 4 hours.5 Apoquel is given twice daily for up to 14 days, and then given once daily for maintenance therapy. You can use for both short-term or long-term therapy in your dog and discontinue use without tapering. Since Apoquel is neither a steroid nor an antihistamine, your dog will avoid many of the unpleasant side effects that are often associated with these medications. In a 5-year safety review, the most common individual side effects reported with Apoquel were vomiting, diarrhea, lethargy, anorexia, and bloodwork changes.9 The most common reported side-effects occurred at a rate of less than one dog reacting out of 10,000 dogs treated.10 Apoquel Chewable (oclacitinib chewable tablet) is now available and is another easy-to-administer option if your dog is difficult to pill. Both Apoquel Tablet and Apoquel Chewable are available by prescription only. Talk to your veterinarian about which is best for your dog.

References:
*Vets, n=250, Pet Owners, n=491
1. Data on file, PetTrak Total Unique Patient Count, December 2022, Zoetis Inc. (TI-09437)
2. Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022 (TI-09898)
3. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi:10.1111/vde.12194 (AR-01949)
4. Data on file: Study Report A461N-US-21-B66, Zoetis Inc. 2022
5. FOI Apoquel Chewable FOI Summary: 2023/06/09 Original NADA 141-555 (v2.0).
6. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL)is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Therapy. 2014;37(4)317-24. doi:10.1111/jvp.12101 (AR-00542)
7. Data on file, Apoquel Cytopoint Vet Tracker Wave 11 (December 20 2018) (TI-04447)
8. Data on file, APOQUEL/CYTOPOINT Pet Owner Tracker Wave 11, 2022, Zoetis Inc. (TI- 08418)
9. Data on file. A Five-Year Post-Approval Safety Review for Apoquel® in the US (May 2013 to August 2018), Zoetis Inc (TI-04506)
10. Volume 6C Summary of the Product Characteristics: SPC European Commission, Brussels. 1 Vol. 6C. July 10, 2006, 1-11. (AR-08728)

*Please note: The images provided are for illustrative purposes. Your product may be delivered in a Vetsource Pharmacy vial; product packaging & appearance may vary and are subject to manufacturer availability.

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.



For
Dogs (12 months of age and older)

Active ingredient(s)
Oclacitinib maleate

Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.

Brand name
Apoquel Tablets

Drug class
Janus Kinase (JAK) inhibitor, Immunomodulator

Manufacturer
Zoetis

Product strength & size
Apoquel Tablets may be available in multiple strengths and/or sizes. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.
For current availability, please refer to the product selection above.



Usage
Apoquel Tablets should be given orally as directed by your veterinarian. Wash your hands thoroughly with soap and water immediately after handling the medication.
Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Contact your veterinarian if your pet’s condition worsens or does not improve after starting the medication.

Apoquel Tablets may be administered with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.

Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give more medication than prescribed or two doses at once.

Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 104°F). Any remaining half-tablets should be stored in the original package and used for the next dose.
Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.



Side effects
This medication is generally well tolerated. The most common side effects with this medication are vomiting, diarrhea, decreased appetite, and lethargy. These effects usually diminish over time.
Other reported side effects include (but may not be limited to) elevated liver enzymes, dermatitis, seizures, and increased thirst.

This medication may increase your pet’s susceptibility to infection, including demodicosis, and exacerbation of neoplastic conditions.
Contact your veterinarian immediately if you notice signs of an infection (e.g., increased itching, bleeding or oozing skin sores, painful urination, etc.), any new and abnormal skin changes/growths, or enlargement of existing skin masses.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.

Precautions
Approved for oral use in dogs only- not for human use.

Do NOT administer this medication to dogs less than 12 months of age, or those with serious infections.
Do NOT administer this medication to breeding, pregnant, or lactating animals.

Use with caution in animals with recurrent or preexisting conditions including demodicosis, urinary tract infection, severe infections, and neoplastic conditions (e.g., cancer).

Wash your hands immediately after handling this medication. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes, then seek medical attention. In case of accidental ingestion, seek medical attention immediately.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Drug and food interactions
This medication should be used with caution in animals receiving any other medications that may suppress the immune system.

The following drugs* may have potential interactions with this medication: corticosteroids (e.g., dexamethasone, prednisone), cyclosporine, methotrexate, and mycophenolate.
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.

Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.


Last revised: 7/28/2025
  • Description

    Product details
    Apoquel (oclacitinib tablet) for Dogs is indicated for the control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. This product is a coated tablet formulation. For the flavored chewable tablet formulation, please see Apoquel Chewable for Dogs.
    • #1 Prescribed Oral Medicine for Allergic Itch1: Apoquel is a revolutionary oral medicine for dogs with allergic itch. Apoquel can be used short-term or for long-term maintenance therapy2,3 in dogs 12 months of age and older.
    • Stops Allergic Itch at the Source4: Apoquel is not a steroid, antihistamine, or cyclosporine (a type of drug that reduces immune system activity). Apoquel is in a different category of medications. Unlike other medicines, Apoquel blocks allergic itch at the source. So, it works at the underlying cause of itch to provide relief fast.
    • Fast-Acting Allergy Itch Relief: If your dog is scratching, licking, or chewing like crazy, you want to provide fast, effective relief. Apoquel Tablets start relieving allergic itch within 4 hours5 and control it within 24 hours2. Apoquel has been prescribed to over 14 million dogs and counting.6
    • Can be used with many other medications3 including: nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines (such as rabies), and allergen-specific immunotherapy (allergy shots or drops). The use of Apoquel has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine.
    • Available in Three Strengths: Apoquel Tablets come in 3.6 mg, 5.4 mg, and 16 mg based on your dog’s body weight. Follow your veterinarian’s instructions for dosing as prescribed. You can administer to your dog orally once a day with or without food. Apoquel is now available in a pork-liver flavored chewable.

    Apoquel Tablets control itching (pruritus) associated with allergic dermatitis and control atopic dermatitis in dogs at least 12 months of age. Apoquel has been prescribed for over 14 million dogs6 and is #1 in pet owner and vet satisfaction for oral medications for allergic itch in dogs*.7,8 It goes right to the source to help stop itching and relieve associated inflammation in affected canines providing relief in as little as 4 hours.5 Apoquel is given twice daily for up to 14 days, and then given once daily for maintenance therapy. You can use for both short-term or long-term therapy in your dog and discontinue use without tapering. Since Apoquel is neither a steroid nor an antihistamine, your dog will avoid many of the unpleasant side effects that are often associated with these medications. In a 5-year safety review, the most common individual side effects reported with Apoquel were vomiting, diarrhea, lethargy, anorexia, and bloodwork changes.9 The most common reported side-effects occurred at a rate of less than one dog reacting out of 10,000 dogs treated.10 Apoquel Chewable (oclacitinib chewable tablet) is now available and is another easy-to-administer option if your dog is difficult to pill. Both Apoquel Tablet and Apoquel Chewable are available by prescription only. Talk to your veterinarian about which is best for your dog.

    References:
    *Vets, n=250, Pet Owners, n=491
    1. Data on file, PetTrak Total Unique Patient Count, December 2022, Zoetis Inc. (TI-09437)
    2. Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022 (TI-09898)
    3. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi:10.1111/vde.12194 (AR-01949)
    4. Data on file: Study Report A461N-US-21-B66, Zoetis Inc. 2022
    5. FOI Apoquel Chewable FOI Summary: 2023/06/09 Original NADA 141-555 (v2.0).
    6. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL)is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Therapy. 2014;37(4)317-24. doi:10.1111/jvp.12101 (AR-00542)
    7. Data on file, Apoquel Cytopoint Vet Tracker Wave 11 (December 20 2018) (TI-04447)
    8. Data on file, APOQUEL/CYTOPOINT Pet Owner Tracker Wave 11, 2022, Zoetis Inc. (TI- 08418)
    9. Data on file. A Five-Year Post-Approval Safety Review for Apoquel® in the US (May 2013 to August 2018), Zoetis Inc (TI-04506)
    10. Volume 6C Summary of the Product Characteristics: SPC European Commission, Brussels. 1 Vol. 6C. July 10, 2006, 1-11. (AR-08728)

    *Please note: The images provided are for illustrative purposes. Your product may be delivered in a Vetsource Pharmacy vial; product packaging & appearance may vary and are subject to manufacturer availability.

    Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.



    For
    Dogs (12 months of age and older)

    Active ingredient(s)
    Oclacitinib maleate

    Inactive ingredients
    Complete inactive ingredients list not provided by manufacturer.

    Brand name
    Apoquel Tablets

    Drug class
    Janus Kinase (JAK) inhibitor, Immunomodulator

    Manufacturer
    Zoetis

    Product strength & size
    Apoquel Tablets may be available in multiple strengths and/or sizes. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.
    For current availability, please refer to the product selection above.



    Usage
    Apoquel Tablets should be given orally as directed by your veterinarian. Wash your hands thoroughly with soap and water immediately after handling the medication.
    Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Contact your veterinarian if your pet’s condition worsens or does not improve after starting the medication.

    Apoquel Tablets may be administered with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.

    Missed doses
    Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give more medication than prescribed or two doses at once.

    Storage
    Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 104°F). Any remaining half-tablets should be stored in the original package and used for the next dose.
    Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.



    Side effects
    This medication is generally well tolerated. The most common side effects with this medication are vomiting, diarrhea, decreased appetite, and lethargy. These effects usually diminish over time.
    Other reported side effects include (but may not be limited to) elevated liver enzymes, dermatitis, seizures, and increased thirst.

    This medication may increase your pet’s susceptibility to infection, including demodicosis, and exacerbation of neoplastic conditions.
    Contact your veterinarian immediately if you notice signs of an infection (e.g., increased itching, bleeding or oozing skin sores, painful urination, etc.), any new and abnormal skin changes/growths, or enlargement of existing skin masses.

    Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
    If you notice anything unusual, please consult your veterinarian.

    Precautions
    Approved for oral use in dogs only- not for human use.

    Do NOT administer this medication to dogs less than 12 months of age, or those with serious infections.
    Do NOT administer this medication to breeding, pregnant, or lactating animals.

    Use with caution in animals with recurrent or preexisting conditions including demodicosis, urinary tract infection, severe infections, and neoplastic conditions (e.g., cancer).

    Wash your hands immediately after handling this medication. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes, then seek medical attention. In case of accidental ingestion, seek medical attention immediately.

    Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
    If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

    Drug and food interactions
    This medication should be used with caution in animals receiving any other medications that may suppress the immune system.

    The following drugs* may have potential interactions with this medication: corticosteroids (e.g., dexamethasone, prednisone), cyclosporine, methotrexate, and mycophenolate.
    *NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

    Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

    Adverse reactions
    If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

    Overdose
    If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

    For humans:
    The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

    For animals:
    The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
    Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

    *Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.

    Disclaimer
    The content provided on this page is NOT medical advice.
    All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
    Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.


    Last revised: 7/28/2025
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