Product details
Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for Dogs is the broadest* parasite protection of its kind, covering 6 types of parasites in one chewable tablet. It protects against ticks, fleas, heartworm disease, and the three intestinal worms that can be passed to humans — tapeworms, roundworms, and hookworms†.
- Credelio Quattro: The broadest* parasite protection of its kind, covering 6 types of parasites in one chewable tablet.
- Brings peace of mind: This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms†, and tapeworms.
- Easy-to-give chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food.
- Prescription only: Credelio Quattro is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.
- Doses designed for your dog: Credelio Quattro is designed with your furry friend in mind, available in five different weight bands to best match your dog.
Credelio Quattro is effective and works fast where it counts. It kills >99% of fleas within 8 hours of administration and remains effective for an entire month. What's more, Credelio Quattro contains lotilaner that kills ticks‡ twice as fast§ as sarolaner in Simparica Trio and afoxolaner in NexGard1.
This FDA-approved medication delivers all the protection your dog needs in a convenient monthly chewable. It uses four powerful ingredients to provide the broadest* protection that lasts all month long by covering 6 types of parasites. Credelio Quattro comes in a tasty, easy-to-give chewable that's also meat allergy friendly2. In fact, Credelio Quattro was accepted by nearly 9 out of 10 dogs.
References:
*Based on label comparison of the number of parasite types covered in a chewable that also targets ticks.
†Uncinaria stenocephala
‡Amblyomma americanum (lone star tick)
§Based on time to statistical significance vs. control in a head-to-head study. The study compared Credelio® (lotilaner)—not Credelio Quattro™, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the active ingredients in Simparica Trio® (sarolaner, moxidectin, and pyrantel) and NexGard® (afoxolaner).
1. Reif KE. et al. “Comparative speed of kill provided by lotilaner (Credelio®), sarolaner (Simparica Trio®), and afoxolaner (NexGard®) to control Amblyomma americanum infestations on dogs.” Parasite Vectors. 2024 Jul 20;17(1):313.
2. Elanco Animal Health. Data on file.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs (8 weeks of age and older)
Active ingredient(s)
Lotilaner, Moxidectin, Praziquantel, Pyrantel pamoate
Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.
Brand name
Credelio Quattro
Drug class
Isoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Isoquinolone anthelmintic, Tetrahydropyrimidine anthelmintic
Product flavoring
Credelio Quattro is “beef” flavored*.
*These chewables are crafted for sensitive dogs and are meat allergen-free.
Manufacturer
Elanco
Product strength & size
| Weight range | Lotilaner (per tablet) | Moxidectin (per tablet) | Praziquantel (per tablet) | Pyrantel (per tablet) |
|---|---|---|---|---|
| 3.3 to 6 lbs | 56.25 mg | 0.056 mg | 14.25 mg | 14.25 mg |
| 6.1 to 12 lbs | 112.5 mg | 0.113 mg | 28.5 mg | 28.5 mg |
| 12.1 to 25 lbs | 225 mg | 0.225 mg | 57 mg | 57 mg |
| 25.1 to 50 lbs | 450 mg | 0.45 mg | 114 mg | 114 mg |
| 50.1 to 100* lbs | 900 mg | 0.9 mg | 228 mg | 228 mg |
*For dogs over 100 lbs., administer the appropriate combination of tablets to cover your pet’s body weight.
Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.
Manufacturer Dosage and Administration:
Credelio Quattro is given orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).
Credelio Quattro must be administered with a meal or within 30 minutes after feeding.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro.
Missed doses
If a dose is missed, give Credelio Quattro immediately to resume a monthly dosing schedule and notify your veterinarian. Do not give two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.
Storage
Store in a cool, dry place at a controlled room temperature (59 to 77°F, excursions permitted between 41 and 104°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.
Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
The most common side effects of this medication are diarrhea, vomiting, lethargy, decreased appetite, and dermatitis (e.g., itching, redness, and/or inflammation of the skin).
Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert.
For oral use in dogs only- not for use in humans. Keep this and all drugs out of reach of children. Wash hands after handling. If accidentally ingested, seek medical attention immediately.
Keep Credelio Quattro in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.
Lotilaner, one of the ingredients in Credelio Quattro, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
Prior to administration of Credelio Quattro, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Credelio Quattro is not effective against adult D. immitis.
The safe use of Credelio Quattro in breeding, pregnant, or lactating dogs has not been evaluated. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
There are no documented drug or food interactions with Credelio Quattro.
Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 8/20/2025
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Description
Product detailsCredelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for Dogs is the broadest* parasite protection of its kind, covering 6 types of parasites in one chewable tablet. It protects against ticks, fleas, heartworm disease, and the three intestinal worms that can be passed to humans — tapeworms, roundworms, and hookworms†.- Credelio Quattro: The broadest* parasite protection of its kind, covering 6 types of parasites in one chewable tablet.
- Brings peace of mind: This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms†, and tapeworms.
- Easy-to-give chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food.
- Prescription only: Credelio Quattro is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.
- Doses designed for your dog: Credelio Quattro is designed with your furry friend in mind, available in five different weight bands to best match your dog.
Credelio Quattro is effective and works fast where it counts. It kills >99% of fleas within 8 hours of administration and remains effective for an entire month. What's more, Credelio Quattro contains lotilaner that kills ticks‡ twice as fast§ as sarolaner in Simparica Trio and afoxolaner in NexGard1.This FDA-approved medication delivers all the protection your dog needs in a convenient monthly chewable. It uses four powerful ingredients to provide the broadest* protection that lasts all month long by covering 6 types of parasites. Credelio Quattro comes in a tasty, easy-to-give chewable that's also meat allergy friendly2. In fact, Credelio Quattro was accepted by nearly 9 out of 10 dogs.References:*Based on label comparison of the number of parasite types covered in a chewable that also targets ticks.†Uncinaria stenocephala‡Amblyomma americanum (lone star tick)§Based on time to statistical significance vs. control in a head-to-head study. The study compared Credelio® (lotilaner)—not Credelio Quattro™, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the active ingredients in Simparica Trio® (sarolaner, moxidectin, and pyrantel) and NexGard® (afoxolaner).1. Reif KE. et al. “Comparative speed of kill provided by lotilaner (Credelio®), sarolaner (Simparica Trio®), and afoxolaner (NexGard®) to control Amblyomma americanum infestations on dogs.” Parasite Vectors. 2024 Jul 20;17(1):313.2. Elanco Animal Health. Data on file.Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs (8 weeks of age and older)Active ingredient(s)Lotilaner, Moxidectin, Praziquantel, Pyrantel pamoateInactive ingredientsComplete inactive ingredients list not provided by manufacturer.Brand nameCredelio QuattroDrug classIsoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Isoquinolone anthelmintic, Tetrahydropyrimidine anthelminticProduct flavoringCredelio Quattro is “beef” flavored*.*These chewables are crafted for sensitive dogs and are meat allergen-free.ManufacturerElancoProduct strength & sizeWeight range Lotilaner (per tablet) Moxidectin (per tablet) Praziquantel (per tablet) Pyrantel (per tablet) 3.3 to 6 lbs 56.25 mg 0.056 mg 14.25 mg 14.25 mg 6.1 to 12 lbs 112.5 mg 0.113 mg 28.5 mg 28.5 mg 12.1 to 25 lbs 225 mg 0.225 mg 57 mg 57 mg 25.1 to 50 lbs 450 mg 0.45 mg 114 mg 114 mg 50.1 to 100* lbs 900 mg 0.9 mg 228 mg 228 mg *For dogs over 100 lbs., administer the appropriate combination of tablets to cover your pet’s body weight.Usage*For complete product information, please review the full prescribing information in the manufacturer package insert.Manufacturer Dosage and Administration:Credelio Quattro is given orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).Credelio Quattro must be administered with a meal or within 30 minutes after feeding.Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro.Missed dosesIf a dose is missed, give Credelio Quattro immediately to resume a monthly dosing schedule and notify your veterinarian. Do not give two doses at once.If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.StorageStore in a cool, dry place at a controlled room temperature (59 to 77°F, excursions permitted between 41 and 104°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsThe most common side effects of this medication are diarrhea, vomiting, lethargy, decreased appetite, and dermatitis (e.g., itching, redness, and/or inflammation of the skin).Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the manufacturer package insert.For oral use in dogs only- not for use in humans. Keep this and all drugs out of reach of children. Wash hands after handling. If accidentally ingested, seek medical attention immediately.Keep Credelio Quattro in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.Lotilaner, one of the ingredients in Credelio Quattro, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.Prior to administration of Credelio Quattro, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Credelio Quattro is not effective against adult D. immitis.The safe use of Credelio Quattro in breeding, pregnant, or lactating dogs has not been evaluated. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.Drug and food interactionsThere are no documented drug or food interactions with Credelio Quattro.Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 8/20/2025 -
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