Product Information

Description

Product details

Cyclosporine (modified) is an immunosuppressive agent that is used for the treatment of a variety of inflammatory and immune-mediated conditions in dogs and cats.

Used to help control atopic dermatitis in dogs and allergic dermatitis in cats
Extra-label uses include treatment of inflammatory bowel disease, feline asthma, and preventing kidney transplant rejection in cats.
NOTE: Different formulations of cyclosporine may not be interchangeable; only use the formulation prescribed by your veterinarian.
May be prescribed for other animal species; please consult your veterinarian.
While this drug does not have an FDA-approved indication for all animal uses, it is commonly accepted for veterinarians to prescribe this medication for use in animals.

This product contains a chemical on the Prop 65 List.

*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.

Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For

Dogs and Cats

Active ingredient(s)

Cyclosporine

Common brand names

Atopica, Neoral

Drug class

Immunosuppresant

Product strength & size

This product may be available in multiple strengths and/or sizes; please select the appropriate option for your pet as recommended by your veterinarian.

For current availability, please refer to the product selection above.

Usage

Cyclosporine should be given orally as directed by your veterinarian. If possible, wear gloves when administering this medication. Wash your hands thoroughly with soap and water after handling.

Capsules should be kept sealed in their original packaging until administration and should not be broken, split, or opened.

Cyclosporine (Modified) Capsules can be frozen for 30 to 60 minutes prior to administration to help avoid gastrointestinal side effects (e.g., vomiting).

Dogs should preferably receive this medication on an empty stomach (at least 1 hour before or 2 hours after a meal), while cats can receive this medication with or without food. It is important to be as consistent as possible when administering this medication (e.g., time of day, with/without food).

If your pet vomits or appears unwell after receiving the initial dose on an empty stomach, give future doses frozen or with a small amount of food. If vomiting continues, contact your veterinarian.

Your veterinarian may need to perform bloodwork and/or monitor your pet closely while taking this medication. Do not miss any follow-up visits.

Missed doses

Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.

If your pet is taking this medication for a serious condition (e.g., kidney transplant) and misses a dose, contact your veterinarian.

Storage

Store in a cool, dry place at a controlled room temperature (68 to 77°F). Keep this medication sealed in its original packaging and out of the reach of children and pets. Do not puncture foil and expose capsules until it is time for administration. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Side effects

The most common side effects of this medication are vomiting, diarrhea/soft stools, and decreased appetite. These effects are more likely to appear at the start of treatment (or after a dose change) and usually resolve over time.

Other reported side effects include (but may not be limited to): excessive drooling in cats and lowered energy levels/lethargy.

Contact your veterinarian immediately if your pet has swelling/overgrowth of the gums, significant/ongoing weight loss, complete loss of appetite, unusual behavior changes, shows any signs of infection (e.g., fever, chills, frequent or painful urination), or if you notice yellowing of the skin, whites of the eyes, and/or gums.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

Precautions

*This human-grade generic contains the same active ingredient as the FDA-approved veterinary product Atopica. Different formulations of cyclosporine may not be interchangeable; only use the formulation prescribed by your veterinarian.

Do NOT administer this medication to animals with cancer (or that have a history of cancer), or cats with feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV). This medication is NOT recommended in breeding, pregnant, or lactating animals.

Animals receiving this medication have an increased risk of developing infections. Cats receiving cyclosporine should be kept indoors and prevented from hunting or consuming raw meat; this may help reduce the risk of developing an infection called toxoplasmosis.

Use with caution in animals with diabetes, kidney disease, or an active infection.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.

Human exposure warning

This medication is classified as hazardous due to potential exposure risks in humans, including individuals who are actively trying to conceive, as well as to women who are pregnant, breastfeeding, and those who may become pregnant.

Unopened, intact capsules may not pose the same degree of risk as injectable drugs, which usually require extensive preparation. Cutting, crushing, or otherwise manipulating capsules may increase the risk of exposure. Wearing gloves is recommended when handling this medication, and hands should be washed thoroughly with soap and water afterward (even if gloves are worn).

Drug and food interactions

Animals receiving this medication may have a delayed or reduced immune response to vaccinations. Live and modified-live vaccines should be avoided while receiving this medication.

The following drugs* may have potential interactions with this medication: ACE inhibitors (e.g., benazepril, enalapril), amlodipine, azole antifungals (e.g., fluconazole, itraconazole, ketoconazole), corticosteroids (e.g., dexamethasone, prednisone), digoxin, estriol, fluoroquinolone antibiotics (e.g., ciprofloxacin, enrofloxacin), JAK inhibitors (e.g., ilunocitinib, oclacitinib), loop diuretics (e.g., furosemide, torsemide), methotrexate, mycophenolate, NSAIDs, phenobarbital, sertraline, spironolactone, sulfa antibiotics, telmisartan (Semintra), and warfarin.

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.

Last revised: 5/14/2025

Description
Product details
Cyclosporine (modified) is an immunosuppressive agent that is used for the treatment of a variety of inflammatory and immune-mediated conditions in dogs and cats.
- Used to help control atopic dermatitis in dogs and allergic dermatitis in cats
- Extra-label uses include treatment of inflammatory bowel disease, feline asthma, and preventing kidney transplant rejection in cats.
- NOTE: Different formulations of cyclosporine may not be interchangeable; only use the formulation prescribed by your veterinarian.
- May be prescribed for other animal species; please consult your veterinarian.
- While this drug does not have an FDA-approved indication for all animal uses, it is commonly accepted for veterinarians to prescribe this medication for use in animals.
This product contains a chemical on the Prop 65 List.

*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.

Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For
Dogs and Cats

Active ingredient(s)
Cyclosporine

Common brand names
Atopica, Neoral

Drug class
Immunosuppresant

Product strength & size
This product may be available in multiple strengths and/or sizes; please select the appropriate option for your pet as recommended by your veterinarian.
For current availability, please refer to the product selection above.

Usage
Cyclosporine should be given orally as directed by your veterinarian. If possible, wear gloves when administering this medication. Wash your hands thoroughly with soap and water after handling.
Capsules should be kept sealed in their original packaging until administration and should not be broken, split, or opened.

Cyclosporine (Modified) Capsules can be frozen for 30 to 60 minutes prior to administration to help avoid gastrointestinal side effects (e.g., vomiting).
Dogs should preferably receive this medication on an empty stomach (at least 1 hour before or 2 hours after a meal), while cats can receive this medication with or without food. It is important to be as consistent as possible when administering this medication (e.g., time of day, with/without food).
If your pet vomits or appears unwell after receiving the initial dose on an empty stomach, give future doses frozen or with a small amount of food. If vomiting continues, contact your veterinarian.

Your veterinarian may need to perform bloodwork and/or monitor your pet closely while taking this medication. Do not miss any follow-up visits.

Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
If your pet is taking this medication for a serious condition (e.g., kidney transplant) and misses a dose, contact your veterinarian.

Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F). Keep this medication sealed in its original packaging and out of the reach of children and pets. Do not puncture foil and expose capsules until it is time for administration. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Side effects
The most common side effects of this medication are vomiting, diarrhea/soft stools, and decreased appetite. These effects are more likely to appear at the start of treatment (or after a dose change) and usually resolve over time.
Other reported side effects include (but may not be limited to): excessive drooling in cats and lowered energy levels/lethargy.
Contact your veterinarian immediately if your pet has swelling/overgrowth of the gums, significant/ongoing weight loss, complete loss of appetite, unusual behavior changes, shows any signs of infection (e.g., fever, chills, frequent or painful urination), or if you notice yellowing of the skin, whites of the eyes, and/or gums.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.

Precautions
*This human-grade generic contains the same active ingredient as the FDA-approved veterinary product Atopica. Different formulations of cyclosporine may not be interchangeable; only use the formulation prescribed by your veterinarian.

Do NOT administer this medication to animals with cancer (or that have a history of cancer), or cats with feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV). This medication is NOT recommended in breeding, pregnant, or lactating animals.
Animals receiving this medication have an increased risk of developing infections. Cats receiving cyclosporine should be kept indoors and prevented from hunting or consuming raw meat; this may help reduce the risk of developing an infection called toxoplasmosis.
Use with caution in animals with diabetes, kidney disease, or an active infection.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.

Human exposure warning
This medication is classified as hazardous due to potential exposure risks in humans, including individuals who are actively trying to conceive, as well as to women who are pregnant, breastfeeding, and those who may become pregnant.
Unopened, intact capsules may not pose the same degree of risk as injectable drugs, which usually require extensive preparation. Cutting, crushing, or otherwise manipulating capsules may increase the risk of exposure. Wearing gloves is recommended when handling this medication, and hands should be washed thoroughly with soap and water afterward (even if gloves are worn).

Drug and food interactions
Animals receiving this medication may have a delayed or reduced immune response to vaccinations. Live and modified-live vaccines should be avoided while receiving this medication.
The following drugs* may have potential interactions with this medication: ACE inhibitors (e.g., benazepril, enalapril), amlodipine, azole antifungals (e.g., fluconazole, itraconazole, ketoconazole), corticosteroids (e.g., dexamethasone, prednisone), digoxin, estriol, fluoroquinolone antibiotics (e.g., ciprofloxacin, enrofloxacin), JAK inhibitors (e.g., ilunocitinib, oclacitinib), loop diuretics (e.g., furosemide, torsemide), methotrexate, mycophenolate, NSAIDs, phenobarbital, sertraline, spironolactone, sulfa antibiotics, telmisartan (Semintra), and warfarin.
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.

Last revised: 5/14/2025
0 Reviews