Cyclosporine (Modified) Capsules

Cyclosporine (Modified) Capsules

Cyclosporine (modified) is an immunosuppressive agent approved for the control of atopic dermatitis in dogs and feline allergic dermatitis. It may also be prescribed for off-label use in several other immune-mediated disorders in dogs and cats.

Dogs, Cats

Cyclosporine (Modified)

Atopica®, Neoral®

Immunosuppressant

Manufacturer: Teva Pharmaceuticals USA

Cyclosporine (modified) 25 mg Capsules: 13 mm, oval, yellow soft gelatin capsule, filled with yellowish to yellow-brown oily liquid, not scored, imprinted with [hourglass logo] 25 mg. (NDC 00093-9018-65)

Cyclosporine (modified) 50 mg Capsules: 21 mm, oblong, ochre-yellow soft gelatin capsule, filled with yellowish to yellow-brown oily liquid, not scored, imprinted with [hourglass logo] 50 mg. (NDC 00093-9019-65)

Cyclosporine (modified) 100 mg Capsules: 25 mm, oblong, brown soft gelatin capsule, filled with yellowish to yellow-brown oily liquid, not scored, imprinted with [hourglass logo] 100 mg. (NDC 00093-9020-65)

Cyclosporine

Cyclosporine (modified) 25 mg Capsules: benzyl alcohol, gelatin hydrolysate, propylene glycol monolaurate, titanium dioxide, polyoxyl 35 castor oil, glycerin, polyethylene glycol 400, ferrosoferric oxide, propylene glycol, water, hypromellose 2910 (15000 mPa.s). (Manufacturer: Apotex, NDC 60505-4630-03)

Cyclosporine (modified) 25 mg Capsules: Alcohol, DL-alpha-tocopherol, gelatin, glycine, glycerin, glyceryl monolinoleate, polyoxyl 40 hydrogenated castor oil, propylene glycol, noncrystallizing sorbitol solution, titanium dioxide, ferric oxide yellow. (Manufacturer: Teva Pharmaceuticals USA, NDC 00093-9018-65)

Cyclosporine (modified) 50 mg Capsules: Alcohol, DL-alpha-tocopherol, gelatin, glycine, glycerin, glyceryl monolinoleate, polyoxyl 40 hydrogenated castor oil, propylene glycol, noncrystallizing sorbitol solution, titanium dioxide, ferric oxide yellow (Manufacturer: Teva Pharmaceuticals USA, NDC 00093-9019-65)

Cyclosporine (modified) 100 mg Capsules: Alcohol, DL-alpha-tocopherol, gelatin, glycine, glycerin, glyceryl monolinoleate, polyoxyl 40 hydrogenated castor oil, propylene glycol, noncrystallizing sorbitol solution, titanium dioxide, brown iron oxide. (Manufacturer: Teva Pharmaceuticals USA, NDC 00093-9020-65)

Cyclosporine (Modified) Capsules should be given orally as directed by your veterinarian. Capsules should not be split or opened. Wear gloves when administering this medication if possible and wash your hands after handling this medication.

Cyclosporine (Modified) Capsules can be frozen beforehand (30 to 60 minutes prior to administration) to help avoid GI side effects (e.g., vomiting, etc.).

Give this medication to your pet exactly as instructed by your veterinarian. Do not open original packaging (foil blister) until you are ready to administer the dose. Capsules should not be broken, split, or opened.

This medication is given preferably with or after a meal. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food. If vomiting continues, contact your veterinarian.

Your veterinarian may need to perform bloodwork and/or monitor your pet closely while taking this medication. Do not miss any follow-up visits.

Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.

If your pet is taking this medication for a serious condition (e.g., kidney transplant), contact your veterinarian if a dose is missed.

Common side effects associated with this medication may include appetite loss, soft stools/diarrhea, and vomiting. These effects may be more likely to appear at the beginning of treatment (or after a dose change); in many cases, these effects should decrease or resolve over time.

Notify your veterinarian if the effects described above appear and become persistent or troublesome. Other side effects may occur. If you notice anything unusual, contact your veterinarian.

The following medications may have potential interactions with this medication (but may not be a comprehensive list): azole antifungals, corticosteroids, NSAIDs, olacitinib (Apoquel- especially long-term use), phenobarbital, sulfonamides, telmisartan (Semintra).

Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosage(s) or monitor your pet more closely.

While this human-grade generic formulation does not have an FDA-approved indication for animal use, it is a common and acceptable practice for veterinarians to prescribe this formulation for use in animals.

Administration of this medication to pregnant or breeding animals is not recommended and should only be considered during pregnancy in cases where the potential benefit outweighs risk. Use in lactating animals is not recommended.

Do not administer to animals with known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.

This medication may represent a hazard to males or females who are actively trying to conceive, women who are pregnant or may become pregnant, and women who are breastfeeding (due to possible distribution into maternal breast milk). Unopened, intact tablets and capsules may not pose the same degree of risk as injectable drugs that usually require extensive preparation. Cutting, crushing, or otherwise manipulating tablets and capsules will increase the risk of exposure. Wear gloves while handling this medication. Wash your hands thoroughly with soap and water after handling this medication. In case of accidental ingestion, seek medical advice immediately and be prepared to provide medication information.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource customer service at 877-738-4443.

Store in a cool, dry place at a controlled room temperature (68 to 77°F). Keep this medication in the original packaging and out of the reach of children and pets. Do not puncture foil packaging and expose capsules until the dose is being administered. Store away from heat and direct sunlight. Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.