Interceptor PLUS

Interceptor Plus (milbemycin oxime/praziquantel) for Dogs is a monthly chewable tablet indicated for the prevention of heartworm disease and for the treatment and control of common intestinal parasites, including adult roundworm, hookworm, whipworm, and tapeworm infections.

If your dog is only protected from heartworm disease, there’s a gap in their coverage. Close the gap with Interceptor Plus. Interceptor Plus also treats and controls four other major worms including adult roundworm, hookworm, whipworm and tapeworm infections in dogs and puppies. That’s protection against more types of worms than Heartgard Plus. Unlike Interceptor Plus, both Heartgard Plus (ivermectin/pyrantel) and Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) do not cover tapeworm or whipworm.*

When untreated, intestinal worms can cause discomfort and fatigue with diarrhea, weight loss, anemia and more. That’s why Interceptor Plus makes dosing easy and convenient with 5-in-1 protection in a tasty, chicken-flavored chew. No need to hide pills in food-pockets. This chewable heartworm prevention goes down easy and keeps the protection going strong for 30 days. Check the product label for information on dosing and potential side effects.

Interceptor Plus heartworm prevention is only available by prescription. Dogs must be at least six weeks old and weigh 2 - 8 lbs. to use Interceptor Plus.

Never miss a monthly treatment when you subscribe to convenient, regular doorstep deliveries of 1 dose, 6-dose or 12-dose packs. Before starting any heartworm prevention program, it’s important for your veterinarian to test your dog for an existing heartworm infection. At your next visit, tell your veterinarian you want PLUS-level protection for your loyal pup so you can enjoy peace of mind in all of their favorite places – from the backyard to the dog park.

Interceptor Plus is a trademark of Elanco or its affiliates. All other product names are trademarks of their respective owners

*Heartgard Plus protects against heartworm disease, hookworms (A. caninum, U. stenocephala, A. braziliense), and roundworms. Simparica TRIO protects against heartworm disease, hookworms (A. caninum, U. stenocephala), and roundworms.

Dogs (6 weeks of age and older)

Milbemycin oxime, Praziquantel

Complete inactive ingredients list not provided by manufacturer.

Interceptor Plus

Milbemycin antiparasitic, Isoquinolone anthelmintic

Interceptor Plus chewable flavored tablets are chicken flavored.

Elanco

Weight range	Milbemycin oxime (per chewable)	Praziquantel (per chewable)
2 to 8 lbs.	2.3 mg	22.8 mg
8.1 to 25 lbs.	5.75 mg	57 mg
25.1 to 50 lbs.	11.5 mg	114 mg
50.1 to 100 lbs.	23 mg	228 mg

*For dogs over 100 lbs., administer the appropriate combination of chewables to cover your pet’s body weight.

*For complete product information, please review the full prescribing information in the manufacturer package insert.

Manufacturer Dosage and Administration:

Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes.

Interceptor Plus may be offered to the dog by hand or added to a small amount of dog food. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

If a dose is missed: give Interceptor Plus immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Store in a cool, dry place at a controlled room temperature between 59 to 77°F. Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging to protect them from light and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.

Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Interceptor Plus is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, and lowered energy level.

Contact your veterinarian immediately if your pet experiences a shock-like reaction, excessive drooling, seizures, tremors, extreme weakness, or decreased coordination (e.g., staggering, stumbling, difficulty walking).

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

*For complete product information including warnings and precautions, please refer to the manufacturer package insert.

For use in dogs only- not for use in humans.

Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.

Prior to administration of INTERCEPTOR PLUS, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. INTERCEPTOR PLUS is not effective against adult D. immitis.

Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Do not use in puppies less than six weeks of age.

Do not use in dogs or puppies less than two pounds of body weight.

The safety of INTERCEPTOR PLUS has not been evaluated in dogs used for breeding or in lactating females. Studies have been performed with milbemycin oxime alone. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

The following drugs* may have potential interactions with this medication: amiodarone, azole antifungals (e.g., itraconazole, ketoconazole), certain calcium channel blockers (e.g., diltiazem), carvedilol, cyclosporine, dexamethasone, erythromycin, and phenobarbital.

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.