Product details
PrednisoLONE is an intermediate-acting corticosteroid used to help treat hypoadrenocorticism or inflammatory conditions (e.g., asthma, allergies, etc.). It may also be used as an immunosuppressant or as part of a chemotherapy protocol.
*Note: prednisoLONE should not be confused (and is not typically considered interchangeable) with predniSONE.
- PrednisoLONE has an FDA-approved indication to treat inflammatory conditions in dogs requiring glucocorticoid therapy.
- This medication may also be used in both dogs and cats for a variety of conditions, including hypoadrenocorticism, asthma, and allergies, or to suppress the immune system.
- Can be used in horses to help treat inflammation and immune responses related to asthma, allergies, and other immune disorders
- PrednisoLONE is typically recommended over predniSONE in cats and horses because they absorb this medication more effectively.
- May be used for other animal species; please consult your veterinarian.
While this medication does not have an FDA-approved indication across all animal uses and species, it is a common and acceptable practice for veterinarians to prescribe this human generic medication for use in animals.
*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.
Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs, Cats, and Horses
Active ingredient(s)
Prednisolone
Common brand names
PrednisTab®
Drug class
Glucocorticoid
Product strength & size
This product is available in multiple strengths and sizes; please select the appropriate option for your pet as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
Prednisolone should be given orally as directed by your veterinarian.
Do not discontinue this medication abruptly, especially if your pet has been taking it for two or more weeks. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.
This medication is given preferably with or after a meal. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.
Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
Common side effects may include (but are not limited to): excessive thirst, urination, and appetite.
Other reported side effects include dull/dry haircoat, weight gain, panting, GI effects (vomiting, diarrhea, GI ulceration), muscle wasting, and behavioral changes (e.g., depression, lethargy, aggression).
Contact your veterinarian immediately if your pet stops eating, displays atypically low energy levels, experiences bloody vomiting, or has black, tarry stools.
Many side effects are often linked to high doses or prolonged use but may still occur during short-term therapy. Your veterinarian may provide specific instructions to help avoid or lessen these effects.
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
If your pet is using this medication regularly, please consult your veterinarian before making any changes to the prescribed dosing schedule or discontinuing the medication abruptly.
Do not use this medication if your pet has a current systemic fungal or viral infection, active tuberculosis, demodectic mange, hyperadrenocorticism, or active corneal/GI ulceration.
Use with caution in animals with preexisting congestive heart failure, diabetes, hypertension, osteoporosis, bleeding disorders, or kidney disease.
Steroid medications can weaken your pet's immune system, making it easier for them to get an infection (or worsen an existing one). Vaccines should not typically be administered while on this medication.
Notify your veterinarian if your pet is pregnant or nursing; they may adjust the dosage or monitor your pet more frequently while taking this medication.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.
Drug and food interactions
The following drugs* may have potential interactions with this medication: antidiabetic agents (including insulin), antihypertensives, azole antifungals, (concurrent) corticosteroids, cyclosporine, fluoroquinolone antibiotics, NSAIDs, and phenobarbital.
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.
Last revised: 4/09/2025
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Description
Product detailsPrednisoLONE is an intermediate-acting corticosteroid used to help treat hypoadrenocorticism or inflammatory conditions (e.g., asthma, allergies, etc.). It may also be used as an immunosuppressant or as part of a chemotherapy protocol.*Note: prednisoLONE should not be confused (and is not typically considered interchangeable) with predniSONE.- PrednisoLONE has an FDA-approved indication to treat inflammatory conditions in dogs requiring glucocorticoid therapy.
- This medication may also be used in both dogs and cats for a variety of conditions, including hypoadrenocorticism, asthma, and allergies, or to suppress the immune system.
- Can be used in horses to help treat inflammation and immune responses related to asthma, allergies, and other immune disorders
- PrednisoLONE is typically recommended over predniSONE in cats and horses because they absorb this medication more effectively.
- May be used for other animal species; please consult your veterinarian.
While this medication does not have an FDA-approved indication across all animal uses and species, it is a common and acceptable practice for veterinarians to prescribe this human generic medication for use in animals.*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs, Cats, and HorsesActive ingredient(s)PrednisoloneCommon brand namesPrednisTab®Drug classGlucocorticoidProduct strength & sizeThis product is available in multiple strengths and sizes; please select the appropriate option for your pet as recommended by your veterinarian.For current availability, please refer to the product selection above.UsagePrednisolone should be given orally as directed by your veterinarian.Do not discontinue this medication abruptly, especially if your pet has been taking it for two or more weeks. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.This medication is given preferably with or after a meal. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.Missed dosesAdminister the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.StorageStore in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsCommon side effects may include (but are not limited to): excessive thirst, urination, and appetite.Other reported side effects include dull/dry haircoat, weight gain, panting, GI effects (vomiting, diarrhea, GI ulceration), muscle wasting, and behavioral changes (e.g., depression, lethargy, aggression).Contact your veterinarian immediately if your pet stops eating, displays atypically low energy levels, experiences bloody vomiting, or has black, tarry stools.Many side effects are often linked to high doses or prolonged use but may still occur during short-term therapy. Your veterinarian may provide specific instructions to help avoid or lessen these effects.Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.PrecautionsIf your pet is using this medication regularly, please consult your veterinarian before making any changes to the prescribed dosing schedule or discontinuing the medication abruptly.Do not use this medication if your pet has a current systemic fungal or viral infection, active tuberculosis, demodectic mange, hyperadrenocorticism, or active corneal/GI ulceration.Use with caution in animals with preexisting congestive heart failure, diabetes, hypertension, osteoporosis, bleeding disorders, or kidney disease.Steroid medications can weaken your pet's immune system, making it easier for them to get an infection (or worsen an existing one). Vaccines should not typically be administered while on this medication.Notify your veterinarian if your pet is pregnant or nursing; they may adjust the dosage or monitor your pet more frequently while taking this medication.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.Drug and food interactionsThe following drugs* may have potential interactions with this medication: antidiabetic agents (including insulin), antihypertensives, azole antifungals, (concurrent) corticosteroids, cyclosporine, fluoroquinolone antibiotics, NSAIDs, and phenobarbital.*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.Last revised: 4/09/2025 -
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