Product details
Revolution (selamectin) Topical Solution for Dogs kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution Topical Solution for Dogs is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis in dogs six weeks of age or older.
*For dogs and puppies weighing up to 5 lbs. or less, please see Revolution Topical Solution for Puppies and Kittens.
- 5-in-1 Protection: One simple-to-apply, monthly application protects your dog from fleas, ticks*, ear mites, heartworm disease, and sarcoptes mites. Revolution has a 20+ year history working to protect tens of millions of pets.
- Easy-to-Apply: Revolution doesn't require gloves or separation time. It's quick-drying, pre-measured, and applied topically on the back of your dog's neck. Wash hands after use.
- Control You Can Count On: Effectively treats and controls infestations of common parasites, including American dog ticks* and ear mites, sarcoptic mange, while breaking the flea life cycle by killing adult fleas and preventing flea eggs from hatching.
- Year-Round Heartworm Disease Prevention: When given monthly, Revolution prevents the development of adult heartworms.
- Confidence in Every Application: Approved for dogs 6+ weeks old with no minimum weight. It has been tested safe in over 100 different pure and mixed breeds of healthy dogs, including pregnant & lactating females, breeding males & females, Avermectin-sensitive collies, and heartworm positive dogs.
Revolution (selamectin) is a simple-to-apply, monthly topical solution that protects dogs 6 weeks of age and older with no minimum weight from fleas, ticks*, ear mites, heartworm disease, and sarcoptic mites. Trusted by veterinarians for over 20 years, Revolution has worked to protect tens of millions of pets and it's an FDA-approved medication that, when applied topically, has systemic effects, treating both internal and external parasites. Revolution kills adult fleas and prevents flea eggs from hatching for a full month and is indicated for the prevention and control of flea infestations**, prevention of heartworm disease†, and the treatment and control of ear mite‡ infestations. Revolution is also indicated for the treatment and control of sarcoptic mange§ and for the control of tick infestations¶. Available with a veterinarian prescription only. Ask your vet if Revolution is right for your dog. Save with automatic deliveries and enjoy the convenience and peace of mind that your dog doesn't miss a dose.
*Dermacentor variabilis
**Ctenocephalides felis
†Caused by Dirofilaria immitis
‡Otodectes cynotis
§Sarcoptes scabiei
¶Due to Dermacentor variabilis
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs (6 weeks of age and older)
Active ingredient(s)
Selamectin
Inactive ingredients
Isopropyl alcohol, butylated hydroxytoluene (BHT).
Brand name
Revolution Topical Solution for Dogs
Drug class
Avermectin antiparasitic, Topical
Manufacturer
Zoetis
Product strength & size
| Weight Range | Package color | Selamectin (per tube) | Potency | Volume (per tube) |
|---|---|---|---|---|
| 5.1 to 10 lbs | Purple | 30 mg | 120 mg/mL | 0.25 mL |
| 10.1 to 20 lbs | Brown | 60 mg | 120 mg/mL | 0.5 mL |
| 20.1 to 40 lbs | Red | 120 mg | 120 mg/mL | 1 mL |
| 40.1 to 85 lbs | Teal | 240 mg | 120 mg/mL | 2 mL |
| 85.1 to 130 lbs | Plum | 360 mg | 120 mg/mL | 3 mL |
For dogs over 130 lbs, use the appropriate combination of tubes to cover your pet’s body weight.
Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.
Revolution Topical Solution for Dogs should be applied topically year-round at monthly intervals, or as otherwise directed by your veterinarian.
Manufacturer Dosage and Administration:
The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.
Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the labeled product weight ranges.
A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution topically to dogs prior to first use.
Revolution Topical Solution for Dogs requires no gloves. Apply in just 3 simple steps:
Step 1: Press cap until you hear a “CLICK”. Hold tube upright and press the cap to puncture the seal. Remove cap and make sure tip is open.
Step 2: Part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot.
Step 3: Glide tube, lift, and discard. Keeping the tube squeezed, glide it along the skin and away from the liquid, then lift off. Ensure the tube is empty before throwing it out.
Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolution against fleas or heartworm.
Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product.
Discard empty tubes in your ordinary household trash.
Missed doses
If a dose is missed: apply Revolution immediately to resume monthly dosing and notify your veterinarian. Do not apply two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.
Storage
Store in a cool, dry place at a controlled room temperature below 86°F. Keep out of the reach of children and pets. Tubes should remain sealed in their original packaging and should only be opened at the time of dosing. Store away from heat and direct sunlight.
Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
Revolution Topical Solution is generally well tolerated in dogs and cats, and side effects are considered uncommon when the appropriate product is given at the recommended dosage.
Reported side effects in dogs include (but may not be limited to) lethargy, vomiting, diarrhea, decreased appetite, generalized itching, and application site reactions (including hair loss, lesions, redness, itching, and/or inflammation).
Contact your veterinarian immediately if you notice your pet has a seizure or tremors, extreme tiredness or weakness, decreased coordination (e.g., stumbling), dilated pupils, excessive drooling, or behavioral changes (e.g., depression).
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert.
For topical use on dogs only- not for human use. Keep out of reach of children.
In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching, and skin redness have been reported in humans. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT).
Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately.
This product is flammable. Keep away from heat, sparks, open flames or other sources of ignition.
Do not use in sick, weak, debilitated, or underweight animals.
Prior to administration of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not effective for microfilariae clearance.
Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered Revolution.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
There are no documented drug or food interactions with Revolution Topical Solution.
Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 8/06/2025
-
Description
Product detailsRevolution (selamectin) Topical Solution for Dogs kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution Topical Solution for Dogs is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis in dogs six weeks of age or older.*For dogs and puppies weighing up to 5 lbs. or less, please see Revolution Topical Solution for Puppies and Kittens.- 5-in-1 Protection: One simple-to-apply, monthly application protects your dog from fleas, ticks*, ear mites, heartworm disease, and sarcoptes mites. Revolution has a 20+ year history working to protect tens of millions of pets.
- Easy-to-Apply: Revolution doesn't require gloves or separation time. It's quick-drying, pre-measured, and applied topically on the back of your dog's neck. Wash hands after use.
- Control You Can Count On: Effectively treats and controls infestations of common parasites, including American dog ticks* and ear mites, sarcoptic mange, while breaking the flea life cycle by killing adult fleas and preventing flea eggs from hatching.
- Year-Round Heartworm Disease Prevention: When given monthly, Revolution prevents the development of adult heartworms.
- Confidence in Every Application: Approved for dogs 6+ weeks old with no minimum weight. It has been tested safe in over 100 different pure and mixed breeds of healthy dogs, including pregnant & lactating females, breeding males & females, Avermectin-sensitive collies, and heartworm positive dogs.
Revolution (selamectin) is a simple-to-apply, monthly topical solution that protects dogs 6 weeks of age and older with no minimum weight from fleas, ticks*, ear mites, heartworm disease, and sarcoptic mites. Trusted by veterinarians for over 20 years, Revolution has worked to protect tens of millions of pets and it's an FDA-approved medication that, when applied topically, has systemic effects, treating both internal and external parasites. Revolution kills adult fleas and prevents flea eggs from hatching for a full month and is indicated for the prevention and control of flea infestations**, prevention of heartworm disease†, and the treatment and control of ear mite‡ infestations. Revolution is also indicated for the treatment and control of sarcoptic mange§ and for the control of tick infestations¶. Available with a veterinarian prescription only. Ask your vet if Revolution is right for your dog. Save with automatic deliveries and enjoy the convenience and peace of mind that your dog doesn't miss a dose.*Dermacentor variabilis**Ctenocephalides felis†Caused by Dirofilaria immitis‡Otodectes cynotis§Sarcoptes scabiei¶Due to Dermacentor variabilisProduct sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs (6 weeks of age and older)Active ingredient(s)SelamectinInactive ingredientsIsopropyl alcohol, butylated hydroxytoluene (BHT).Brand nameRevolution Topical Solution for DogsDrug classAvermectin antiparasitic, TopicalManufacturerZoetisProduct strength & sizeWeight Range Package color Selamectin (per tube) Potency Volume (per tube) 5.1 to 10 lbs Purple 30 mg 120 mg/mL 0.25 mL 10.1 to 20 lbs Brown 60 mg 120 mg/mL 0.5 mL 20.1 to 40 lbs Red 120 mg 120 mg/mL 1 mL 40.1 to 85 lbs Teal 240 mg 120 mg/mL 2 mL 85.1 to 130 lbs Plum 360 mg 120 mg/mL 3 mL For dogs over 130 lbs, use the appropriate combination of tubes to cover your pet’s body weight.Usage*For complete product information, please review the full prescribing information in the manufacturer package insert.Revolution Topical Solution for Dogs should be applied topically year-round at monthly intervals, or as otherwise directed by your veterinarian.Manufacturer Dosage and Administration:The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the labeled product weight ranges.A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution topically to dogs prior to first use.Revolution Topical Solution for Dogs requires no gloves. Apply in just 3 simple steps:Step 1: Press cap until you hear a “CLICK”. Hold tube upright and press the cap to puncture the seal. Remove cap and make sure tip is open.Step 2: Part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot.Step 3: Glide tube, lift, and discard. Keeping the tube squeezed, glide it along the skin and away from the liquid, then lift off. Ensure the tube is empty before throwing it out.Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolution against fleas or heartworm.Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product.Discard empty tubes in your ordinary household trash.Missed dosesIf a dose is missed: apply Revolution immediately to resume monthly dosing and notify your veterinarian. Do not apply two doses at once.If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.StorageStore in a cool, dry place at a controlled room temperature below 86°F. Keep out of the reach of children and pets. Tubes should remain sealed in their original packaging and should only be opened at the time of dosing. Store away from heat and direct sunlight.Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsRevolution Topical Solution is generally well tolerated in dogs and cats, and side effects are considered uncommon when the appropriate product is given at the recommended dosage.Reported side effects in dogs include (but may not be limited to) lethargy, vomiting, diarrhea, decreased appetite, generalized itching, and application site reactions (including hair loss, lesions, redness, itching, and/or inflammation).Contact your veterinarian immediately if you notice your pet has a seizure or tremors, extreme tiredness or weakness, decreased coordination (e.g., stumbling), dilated pupils, excessive drooling, or behavioral changes (e.g., depression).Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the manufacturer package insert.For topical use on dogs only- not for human use. Keep out of reach of children.In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching, and skin redness have been reported in humans. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT).Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately.This product is flammable. Keep away from heat, sparks, open flames or other sources of ignition.Do not use in sick, weak, debilitated, or underweight animals.Prior to administration of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not effective for microfilariae clearance.Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered Revolution.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.Drug and food interactionsThere are no documented drug or food interactions with Revolution Topical Solution.Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 8/06/2025 -
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