Revolution PLUS Topical Soln for Cats

Revolution Plus Topical Solution for Cats prevents heartworm disease; treats and controls roundworm and intestinal hookworm infections; treats and controls ear mite infestations; treats and prevents flea infestations (kills adult fleas); prevents tapeworm infections as a direct result of killing vector fleas on the treated cat; and treats and controls tick infestations with lone star ticks, Gulf Coast ticks, American dog ticks, and black-legged ticks for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

Please note: Due to a manufacturer redesign, the same trusted formulation is receiving new, easier-to-read packaging. Your medication may arrive with this updated packaging, depending on manufacturer availability.

Revolution Plus (selamectin and sarolaner topical solution) is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects your cat against most common feline parasites: fleas, ticks, ear mites, roundworms, hookworms, and heartworm disease. It eliminates the need for multiple treatments, simplifying your cat's parasite control routine. Whether your cat lives an indoor, outdoor, or hybrid lifestyle, they are vulnerable to parasites and would benefit from Revolution Plus. When you choose Revolution Plus, you’re choosing veterinarian’s #1 choice for cats¹ with 20 years of proven protection.* Studies show Revolution Plus kills 4 types of ticks for a full month after one dose, including Lone Star ticks, black-legged ticks (a.k.a. deer ticks) American dog ticks and Gulf Coast ticks.^2,3 Effective results sustained for up to 5 weeks for black-legged or deer tick and American dog tick.^2,4 Revolution Plus kills fleas before they lay eggs and keeps killing for a full five weeks. ⁵ Studies to support FDA approval showed that one dose of Revolution Plus was 100% effective in preventing heartworm disease. It started killing fleas within 6 hours of re-infestations⁵ and killed over 99% of ear mites for a full month, reduced nearly 100% of roundworm and hookworm eggs after a single dose.⁵ Revolution Plus is available by veterinarian prescription only. Ask your vet if Revolution Plus is right for your cat or kitten. Automatic deliveries provide savings, convenience, and the peace of mind that your cat never misses and a dose. Revolution Plus is also eligible for Zoetis Petcare Rewards Program. Enroll today for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet.

*Revolution Plus is veterinarians’ #1 trusted choice in feline parasite protection, built upon the proven 20-year legacy protection of Revolution (selamectin).

References:

1. Vetstreet FTH Projection February 2021. Canine and Feline Flea, Tick, Heartworm Market Share. February 2021. Data on file. Zoetis Inc.

2. Zoetis Data on File, Study Report A186C-US-14-100, 2014.

3. Zoetis Data on File, Study Report A186C-US-14-106, 2014.

4. Zoetis Data on File, Study Report A186C-US-14-098, 2014.

5. Revolution Plus (selamectin and sarolaner topical solution). Package insert. Zoetis Inc; 2018.

6. Zoetis Data on File, Study Report A181C-US-15-166, 2017.

Cats (8 weeks of age and older)

Selamectin, Sarolaner

Dipropylene Glycol Monomethylether, Isopropyl Alcohol, Butylated Hydroxytoluene.

Revolution Plus

Avermectin antiparasitic, Isoxazoline ectoparasiticide, Topical

Zoetis

Weight Range	Tube cap color	Tube volume	Selamectin (per tube)	Sarolaner (per tube)
2.8 to 5.5 lbs	Gold	0.25 mL	15 mg	2.5 mg
5.6 to 11 lbs	Orange	0.5 mL	30 mg	5 mg
11.1 to 22* lbs	Green	1 mL	60 mg	10 mg

*Cats over 22 lbs. should be treated with the appropriate combination of tubes to cover your pet’s body weight.

Revolution Plus Topical Solution for Cats should be applied year-round at monthly intervals, or as otherwise directed by your veterinarian.

Manufacturer Dosage and Administration:

The recommended minimum dosage is 2.7 mg selamectin per pound (6 mg/kg) of body weight and 0.45 mg sarolaner per pound (1 mg/kg) of body weight.

Administer the entire contents of a single tube (or two tubes in combination for cats weighing over 22 pounds) of Revolution Plus topically in accordance with the labeled product weight ranges.

A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution Plus topically to cats and kittens prior to first use.

Revolution Plus requires no gloves. Apply in just 3 simple steps:

Step 1: Press cap until you hear a “CLICK”. Hold tube upright and press the cap to puncture the seal. Remove cap and make sure tip is open.

Step 2: Part neck hair and squeeze tube. Part the fur at the base of your cat’s neck and touch tube tip to visible skin. Squeeze tube 3 or 4 times in one spot until empty.

Step 3: Glide tube, lift, and discard. Keeping the tube squeezed, glide it along the skin and away from the liquid, then lift off. Ensure the tube is empty before throwing it out.

Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the hair coat is wet.

Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some cats. These effects are temporary and do not affect the safety or effectiveness of the product.

Discard empty tubes in your ordinary household trash.

If a dose is missed: apply Revolution Plus immediately to resume monthly dosing and notify your veterinarian. Do not apply two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Store in a cool, dry place at a controlled room temperature (at or below 86°F). Keep out of the reach of children and pets. Tubes should remain sealed in their original packaging and should only be opened at the time of dosing. Store away from heat and direct sunlight.

Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Revolution Plus is generally well tolerated in cats, and side effects are considered uncommon when given at the recommended dosage. Reported side effects include (but may not be limited to) lethargy, non-application site skin lesions, decreased appetite, vomiting, diarrhea, itching, conjunctivitis (redness, irritation, and/or inflammation in the eyes), sneezing, and application site reactions (e.g., hair loss, lesions).

Contact your veterinarian immediately if you notice your pet has a seizure or tremors, extreme tiredness or weakness, decreased coordination (e.g., stumbling), dilated pupils, excessive drooling, or behavioral changes (e.g., depression, hyperactivity).

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

*For complete product information including warnings and precautions, please refer to the manufacturer package insert.

For topical use on cats only- not for use in humans.

Revolution Plus may be irritating to the skin and eyes in humans. Do not come into contact with or allow children to contact the application site until 4 hours post-application. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, flush eyes copiously with water for 5 – 10 minutes, then seek medical attention. In case of ingestion by a human, contact a physician immediately.

This product is flammable. Keep away from heat, sparks, open flames or other sources of ignition.

Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders.

The safe use of Revolution Plus has not been evaluated in kittens less than 8 weeks of age. The safe use of Revolution Plus has not been evaluated in breeding, pregnant, or lactating cats. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

There are no documented drug or food interactions with Revolution Plus.

Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.