Name: Sentinel Flavor Tabs
Brand: Merck
Availability: InStock

Product Information

Description

Product details

SENTINEL FLAVOR TABS (milbemycin oxime / lufenuron) for Dogs are indicated for the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations*; the control of adult Ancylostoma caninum (hookworm); and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworm) and Trichuris vulpis (whipworm) infections in dogs and puppies four weeks of age and older, and weighing two pounds of body weight or greater.

Protects against 5 different kinds of parasites.
Unique to SENTINEL brand products, lufenuron prevents flea eggs from hatching.¹
Protects against heartworms, hookworms, roundworms, and whipworms.¹
SENTINEL FLAVOR TABS does all this with once-a-month, pork liver-flavored tablets dogs love.^2,3

*Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas.

Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.

References:

1. SENTINEL® FLAVOR TABS® [prescribing information] Madison, NJ: Merck Animal Health; 2020.

2. SENTINEL® FLAVOR TABS® [Freedom of Information] NADA #141-084.

3. Data on file. Merck Animal Health.

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For

Dogs (4 weeks of age and older)

Active ingredient(s)

Milbemycin oxime, Lufenuron

Inactive ingredients

Complete inactive ingredients list not provided by manufacturer.

Brand name

SENTINEL FLAVOR TABS

Drug class

Milbemycin antiparasitic, Insect development inhibitor

Product flavoring

SENTINEL FLAVOR TABS for Dogs are pork liver flavored.

*Contains pork, soy, lactose

Manufacturer

Merck Animal Health

Product strength & size

Weight Range	Milbemycin oxime (per tablet)	Lufenuron (per tablet)
2 to 10 lbs.	2.3 mg	46 mg
11 to 25 lbs.	5.75 mg	115 mg
26 to 50 lbs.	11.5 mg	230 mg
51 to 100 lbs.	23 mg	460 mg

*For dogs over 100 lbs., administer the appropriate combination of tablets to cover your pet’s body weight.

Usage

*For complete product information, please review the full prescribing information in the manufacturer package insert.

Manufacturer Dosage and Administration:

SENTINEL FLAVOR TABS are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10mg/kg) lufenuron. For dogs over 100 lbs., administer the appropriate combination of tablets.

SENTINEL FLAVOR TABS are palatable, and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets.

Administer SENTINEL FLAVOR TABS to dogs immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible.

SENTINEL FLAVOR TABS must be administered monthly, preferably on the same date each month. Treatment with SENTINEL FLAVOR TABS may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of "mosquito and flea season." In areas with year-round infestations, treatment should continue through the entire year without interruption.

If a dose is missed and a 30-day interval between dosing is exceeded, administer SENTINEL FLAVOR TABS immediately and resume the monthly dosing schedule. If SENTINEL FLAVOR TABS replace daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.

Missed doses

If a dose is missed: give SENTINEL FLAVOR TABS immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Storage

Store in a cool, dry place at a controlled room temperature, between 59 and 77°F. Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.

Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Side effects

SENTINEL FLAVOR TABS are generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. Reported side effects include (but may not be limited to) vomiting, depression/lethargy, itching, skin reactions (e.g., redness, rash), diarrhea, decreased appetite, decreased coordination, salivation/drooling, and weakness.

Contact your veterinarian immediately if your pet experiences a shock-like reaction, severe or persistent vomiting, excessive drooling, fainting/collapse, or if you notice your pet has a seizure, extreme weakness/tiredness, dilated pupils, or severely decreased coordination (e.g., stumbling, difficulty walking).

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

Precautions

*For complete product information including warnings and precautions, please refer to the manufacturer package insert.

For oral use in dogs only- not for use in humans. Keep this and all drugs out of the reach of children.

Do not use in puppies less than four weeks of age and less than two pounds of body weight.

Prior to administration of SENTINEL FLAVOR TABS, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL FLAVOR TABS.

Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

SENTINEL FLAVOR TABS immediately break the flea life cycle by inhibiting egg development. However, preexisting flea populations may continue to develop and emerge after treatment with SENTINEL FLAVOR TABS has begun. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days.

Therefore, noticeable control may not be observed until several weeks after dosing when a preexisting infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. The concurrent use of an approved adulticide may be employed depending on the severity of the infestation.

If a SENTINEL FLAVOR TABS-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. These adult fleas are unable to produce viable offspring. The temporary use of an adulticide product may be necessary to kill these adult fleas.

The safety of SENTINEL FLAVOR TABS has not been established and should be used with caution in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Drug and food interactions

The following drugs* may have potential interactions with this medication: amiodarone, azole antifungals (e.g., itraconazole, ketoconazole), certain calcium channel blockers (e.g., diltiazem, verapamil), carvedilol, cyclosporine, and macrolide antibiotics (e.g., erythromycin).

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Merck Animal Health at 1-800-224-5318 or Vetsource Pet Owner Care at 877-738-4443.

Overdose

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.

Disclaimer

The content provided on this page is NOT medical advice.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.

Last revised: 8/04/2025

Description
Product details
SENTINEL FLAVOR TABS (milbemycin oxime / lufenuron) for Dogs are indicated for the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations*; the control of adult Ancylostoma caninum (hookworm); and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworm) and Trichuris vulpis (whipworm) infections in dogs and puppies four weeks of age and older, and weighing two pounds of body weight or greater.
- Protects against 5 different kinds of parasites.
- Unique to SENTINEL brand products, lufenuron prevents flea eggs from hatching.¹
- Protects against heartworms, hookworms, roundworms, and whipworms.¹
- SENTINEL FLAVOR TABS does all this with once-a-month, pork liver-flavored tablets dogs love.^2,3
*Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas.
Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.

References:
1. SENTINEL® FLAVOR TABS® [prescribing information] Madison, NJ: Merck Animal Health; 2020.
2. SENTINEL® FLAVOR TABS® [Freedom of Information] NADA #141-084.
3. Data on file. Merck Animal Health.

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For
Dogs (4 weeks of age and older)

Active ingredient(s)
Milbemycin oxime, Lufenuron

Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.

Brand name
SENTINEL FLAVOR TABS

Drug class
Milbemycin antiparasitic, Insect development inhibitor

Product flavoring
SENTINEL FLAVOR TABS for Dogs are pork liver flavored.
*Contains pork, soy, lactose

Manufacturer
Merck Animal Health

Product strength & size

Weight Range Milbemycin oxime (per tablet) Lufenuron (per tablet)
2 to 10 lbs. 2.3 mg 46 mg
11 to 25 lbs. 5.75 mg 115 mg
26 to 50 lbs. 11.5 mg 230 mg
51 to 100 lbs. 23 mg 460 mg

*For dogs over 100 lbs., administer the appropriate combination of tablets to cover your pet’s body weight.

Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.

Manufacturer Dosage and Administration:
SENTINEL FLAVOR TABS are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10mg/kg) lufenuron. For dogs over 100 lbs., administer the appropriate combination of tablets.

SENTINEL FLAVOR TABS are palatable, and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets.

Administer SENTINEL FLAVOR TABS to dogs immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible.

SENTINEL FLAVOR TABS must be administered monthly, preferably on the same date each month. Treatment with SENTINEL FLAVOR TABS may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of "mosquito and flea season." In areas with year-round infestations, treatment should continue through the entire year without interruption.

If a dose is missed and a 30-day interval between dosing is exceeded, administer SENTINEL FLAVOR TABS immediately and resume the monthly dosing schedule. If SENTINEL FLAVOR TABS replace daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.

Missed doses
If a dose is missed: give SENTINEL FLAVOR TABS immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Storage
Store in a cool, dry place at a controlled room temperature, between 59 and 77°F. Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.
Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Side effects
SENTINEL FLAVOR TABS are generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. Reported side effects include (but may not be limited to) vomiting, depression/lethargy, itching, skin reactions (e.g., redness, rash), diarrhea, decreased appetite, decreased coordination, salivation/drooling, and weakness.

Contact your veterinarian immediately if your pet experiences a shock-like reaction, severe or persistent vomiting, excessive drooling, fainting/collapse, or if you notice your pet has a seizure, extreme weakness/tiredness, dilated pupils, or severely decreased coordination (e.g., stumbling, difficulty walking).

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.

Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert.

For oral use in dogs only- not for use in humans. Keep this and all drugs out of the reach of children.

Do not use in puppies less than four weeks of age and less than two pounds of body weight.
Prior to administration of SENTINEL FLAVOR TABS, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL FLAVOR TABS.
Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

SENTINEL FLAVOR TABS immediately break the flea life cycle by inhibiting egg development. However, preexisting flea populations may continue to develop and emerge after treatment with SENTINEL FLAVOR TABS has begun. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days.
Therefore, noticeable control may not be observed until several weeks after dosing when a preexisting infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. The concurrent use of an approved adulticide may be employed depending on the severity of the infestation.
If a SENTINEL FLAVOR TABS-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. These adult fleas are unable to produce viable offspring. The temporary use of an adulticide product may be necessary to kill these adult fleas.

The safety of SENTINEL FLAVOR TABS has not been established and should be used with caution in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Drug and food interactions
The following drugs* may have potential interactions with this medication: amiodarone, azole antifungals (e.g., itraconazole, ketoconazole), certain calcium channel blockers (e.g., diltiazem, verapamil), carvedilol, cyclosporine, and macrolide antibiotics (e.g., erythromycin).
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Merck Animal Health at 1-800-224-5318 or Vetsource Pet Owner Care at 877-738-4443.

Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.

Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.

Last revised: 8/04/2025
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