Product details
Simparica Trio is a pork liver-flavored chewable tablet administered once per month to protect your dog from heartworm disease, fleas, ticks, roundworms, and hookworms.
Please note: Due to a manufacturer redesign, the same trusted formulation is receiving new, easier-to-read packaging. Your medication may arrive with this updated packaging, depending on manufacturer availability.
- Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
- Studies to support FDA-approval showed one dose provided 100% protection against heartworm disease.
- Simparica Trio is the first FDA-approved product of its kind and the only one approved to prevent Lyme infections as a direct result of killing deer ticks. It’s proven to kill five types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick.
- Prevents flea infestation by killing fleas before they can even lay eggs. Starts killing within 4 hours and achieved 100% effectiveness in 8 hours in a study. Treats roundworms and hookworms to protect your dog from intestinal parasites.
- Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month with or without food. In a study 9 out of 10 dogs voluntarily consumed this tasty liver-flavored chew.1
Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds, Simparica Trio begins working against fleas in just four hours and kills five types of ticks - including the deer tick that may cause Lyme disease. Just one tasty liver-flavored chew does the job of two or three parasite medications, and in a study nine out of 10 dogs ate Simparica Trio voluntarily.1 It can be given with or without food. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Trust the #1 heartworm disease preventative chosen by veterinarians2 and prescribed to over 7 million patients.3 Available by veterinarian prescription only. Ask your vet if Simparica Trio is right for your dog.
References:
1. Study A161C-US-15-634. Data on file. Zoetis Inc.
2. Heartworm Disease Preventative; DVM 360 ’22 Survey.
3. Kynetec Purchasing Data Vet Clinics Q3 QBR
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs (8 weeks of age and older)
Active ingredient(s)
Sarolaner, Moxidectin, Pyrantel pamoate
Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.
Brand name
Simparica Trio
Drug class
Isoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Tetrahydropyrimidine anthelmintic
Product flavoring
Simparica Trio is a pork liver flavored chewable tablet.
*Contains pork, soy, lactose, corn, wheat
Manufacturer
Zoetis
Product strength & size
| Weight Range | Sarolaner (per tablet) | Moxidectin (per tablet) | Pyrantel (per tablet) |
|---|---|---|---|
| 2.8 to 5.5 lbs | 3 mg | 0.06 mg | 12.5 mg |
| 5.6 to 11 lbs | 6 mg | 0.12 mg | 25 mg |
| 11.1 to 22 lbs | 12 mg | 0.24 mg | 50 mg |
| 22.1 to 44 lbs | 24 mg | 0.48 mg | 100 mg |
| 44.1 to 88 lbs | 48 mg | 0.96 mg | 200 mg |
| 88.1 to 132 lbs | 72 mg | 1.44 mg | 300 mg |
*For dogs over 132 lbs, administer the appropriate combination of tablets to cover your pet’s body weight.
Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.
Simparica Trio should be given orally at monthly intervals year-round, or as otherwise directed by your veterinarian.
Do NOT remove tablets from the foil blister pack until just before administration. The sealed blister pack should be kept in its original box/packaging for protection from environmental factors (e.g., light, moisture).
Manufacturer Dosage and Administration:
Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).
Simparica Trio can be offered to the dog with or without food.
Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.
Missed doses
If a dose is missed: give Simparica Trio immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.
Storage
Store in a cool, dry place at a controlled room temperature (at or below 86°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.
Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
Simparica Trio is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, and lowered energy level.
Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert.
For oral use in dogs only- not for use in humans.
Sarolaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. immitis.
The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.
Drug and food interactions
There are no documented drug or food interactions with Simparica Trio.
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 7/29/2025
-
Description
Product detailsSimparica Trio is a pork liver-flavored chewable tablet administered once per month to protect your dog from heartworm disease, fleas, ticks, roundworms, and hookworms.Please note: Due to a manufacturer redesign, the same trusted formulation is receiving new, easier-to-read packaging. Your medication may arrive with this updated packaging, depending on manufacturer availability.- Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
- Studies to support FDA-approval showed one dose provided 100% protection against heartworm disease.
- Simparica Trio is the first FDA-approved product of its kind and the only one approved to prevent Lyme infections as a direct result of killing deer ticks. It’s proven to kill five types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick.
- Prevents flea infestation by killing fleas before they can even lay eggs. Starts killing within 4 hours and achieved 100% effectiveness in 8 hours in a study. Treats roundworms and hookworms to protect your dog from intestinal parasites.
- Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month with or without food. In a study 9 out of 10 dogs voluntarily consumed this tasty liver-flavored chew.1
Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds, Simparica Trio begins working against fleas in just four hours and kills five types of ticks - including the deer tick that may cause Lyme disease. Just one tasty liver-flavored chew does the job of two or three parasite medications, and in a study nine out of 10 dogs ate Simparica Trio voluntarily.1 It can be given with or without food. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Trust the #1 heartworm disease preventative chosen by veterinarians2 and prescribed to over 7 million patients.3 Available by veterinarian prescription only. Ask your vet if Simparica Trio is right for your dog.References:1. Study A161C-US-15-634. Data on file. Zoetis Inc.2. Heartworm Disease Preventative; DVM 360 ’22 Survey.3. Kynetec Purchasing Data Vet Clinics Q3 QBRProduct sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs (8 weeks of age and older)Active ingredient(s)Sarolaner, Moxidectin, Pyrantel pamoateInactive ingredientsComplete inactive ingredients list not provided by manufacturer.Brand nameSimparica TrioDrug classIsoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Tetrahydropyrimidine anthelminticProduct flavoringSimparica Trio is a pork liver flavored chewable tablet.*Contains pork, soy, lactose, corn, wheatManufacturerZoetisProduct strength & sizeWeight Range Sarolaner (per tablet) Moxidectin (per tablet) Pyrantel (per tablet) 2.8 to 5.5 lbs 3 mg 0.06 mg 12.5 mg 5.6 to 11 lbs 6 mg 0.12 mg 25 mg 11.1 to 22 lbs 12 mg 0.24 mg 50 mg 22.1 to 44 lbs 24 mg 0.48 mg 100 mg 44.1 to 88 lbs 48 mg 0.96 mg 200 mg 88.1 to 132 lbs 72 mg 1.44 mg 300 mg *For dogs over 132 lbs, administer the appropriate combination of tablets to cover your pet’s body weight.Usage*For complete product information, please review the full prescribing information in the manufacturer package insert.Simparica Trio should be given orally at monthly intervals year-round, or as otherwise directed by your veterinarian.Do NOT remove tablets from the foil blister pack until just before administration. The sealed blister pack should be kept in its original box/packaging for protection from environmental factors (e.g., light, moisture).Manufacturer Dosage and Administration:Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).Simparica Trio can be offered to the dog with or without food.Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.Missed dosesIf a dose is missed: give Simparica Trio immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.StorageStore in a cool, dry place at a controlled room temperature (at or below 86°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsSimparica Trio is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, and lowered energy level.Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the manufacturer package insert.For oral use in dogs only- not for use in humans.Sarolaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. immitis.The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.Drug and food interactionsThere are no documented drug or food interactions with Simparica Trio.*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 7/29/2025 -
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