SMZ TMP DS Tablets

SMZ TMP DS (sulfamethoxazole/trimethoprim double strength) is a broad-spectrum, potentiated sulfonamide antimicrobial used to treat a wide range of bacterial and protozoal infections in animals. This product is a tablet formulation.

*Please note: This is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.

Dogs, Cats, and Horses

Sulfamethoxazole, Trimethoprim

Bactrim DS, Septra DS

Potentiated sulfonamide antimicrobial

This product contains 800 mg of sulfamethoxazole and 160 mg of trimethoprim in each Double Strength tablet. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.

For current availability, please refer to the product selection above.

SMZ TMP DS Tablets should be given orally as directed by your veterinarian. Wash your hands thoroughly with soap and water after handling the medication. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.

Ensure your pet always has access to fresh, clean drinking water while taking this medication.

Individuals with a sulfa drug allergy should avoid handling this medication if possible. If handling is necessary, wear gloves and wash your hands thoroughly with soap and water afterward (even if gloves are worn).

Administer the complete course of the medication as prescribed, even if your pet's condition has improved. Failure to administer the entire course of treatment may cause recurrence or worsening of the infection. Contact your veterinarian ahead of time if your pet needs a refill.

Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.

Store in a cool, dry place at a controlled room temperature (68 to 77°F, brief excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

The side effect profile of this medication may vary by animal species; in general, the most common side effects are nausea, vomiting, diarrhea, decreased appetite, and increased salivation or drooling after administration.

Contact your veterinarian immediately if your pet has crystals or blood in the urine; difficulty urinating; redness, discharge, or dryness of the eyes; increased blinking or squinting; skin conditions (e.g., sores, severe itching, hair/fur loss, skin that appears “burned”); increased thirst and/or urination; any signs of an allergic reaction (e.g., difficulty breathing, facial/throat swelling, rash); or if you notice yellowing of the skin, whites of the eyes, and/or gums.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

Do NOT use this medication in animals with severe kidney or liver impairment/disease, blood disorders, or that are dehydrated.

Do NOT use this medication in food animal species.

Individuals with a sensitivity or allergy to sulfonamides should handle this medication carefully; avoid contact of the product with the skin and mucous membranes. Wear gloves when handling the medication if possible and wash your hands thoroughly with soap and water afterward (even if gloves are worn).

Use with caution in certain dog breeds (e.g., Doberman pinschers, Samoyeds, and miniature schnauzers) and animals with folate deficiency, liver/kidney disease, current (or a history of) kidney or bladder stones, or dry eye syndrome.

Safe use of this medication has not been established and may not be recommended in breeding, pregnant, or lactating animals. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to any sulfonamide (“sulfa”) or diaminopyrimidine drug, including this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

The following drugs* may have potential interactions with this medication: ACE inhibitors (e.g., benazepril), amantadine, antacids (containing aluminum, calcium, and/or magnesium), antidiabetic agents (including insulins), ARBs (e.g., telmisartan), aspirin, certain azole antifungals (e.g., fluconazole, ketoconazole), cyclosporine, detomidine (Dormosedan), digoxin, fluoroquinolone antibiotics (e.g., ciprofloxacin), methotrexate, certain NSAIDs (e.g., phenylbutazone), phenobarbital, phenothiazines (e.g., acepromazine), potassium supplements, potassium-sparing diuretics (e.g., spironolactone), pyrimethamine, selegiline, sotalol, SSRIs (e.g., fluoxetine, sertraline), thiazide diuretics (e.g., hydrochlorothiazide), tricyclic antidepressants (e.g., amitriptyline, clomipramine), and warfarin.

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.