Product details
Temaril-P (trimeprazine with prednisolone) is indicated for the relief of allergic itch and its associated inflammation, as well as itch resulting from atopic dermatitis and otitis in dogs. Its synergistic combination of antihistamine and corticosteroid may allow for lower doses of corticosteroids.1 Additionally, it’s found to be an effective therapy in various cough conditions, including “kennel cough,” allergic bronchitis, and other coughs of nonspecific origins. This oral tablet is given daily as prescribed by your vet.
- Three-in-One Therapy: Prescription, oral tablet combines the anti-itch and anti-cough properties of trimeprazine with the anti-inflammatory qualities of prednisolone for a triple therapeutic effect in dogs.
- Multi-Purpose Treatment: Relieves itch and reduces inflammation from allergic & atopic dermatitis, and otitis. It also provides relief from coughing due to “kennel cough,” allergic bronchitis, and other nonspecific forms.
- Powerful & Effective: May relieve itching that doesn’t respond to other treatments.
- Simple Dosing: Twice-daily dosing administered orally as prescribed by your veterinarian.
References:
1. Paradis M, Scott DW, Giroux D. Further investigations on the use of nonsteroidal and steroidal anti-inflammatory agents in the management of canine pruritus. J Am Anim Hosp Assoc. 1991;27:44-48.
*Please note: The images provided are for illustrative purposes. Your product may be delivered in a Vetsource Pharmacy vial; product packaging & appearance may vary and are subject to manufacturer availability.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs
Active ingredient(s)
Trimeprazine tartrate, Prednisolone
Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.
Brand name
Temaril-P
Drug class
Phenothiazine antihistamine, Glucocorticoid
Manufacturer
Zoetis
Product strength & size
Each Temaril-P tablet contains 5 mg of trimeprazine and 2 mg of prednisolone. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
Follow your veterinarian’s instructions as prescribed.
Manufacturer Dosage and Administration:
Up to 10 lbs. – 1/2 (one-half) tablet, twice daily
11-20 lbs. – 1 tablet, twice daily
21-40 lbs. – 2 tablets, twice daily
Over 40 lbs. – 3 tablets, twice daily
After four days, reduce dosage to 1/2 (half) of the initial dose or to an amount just sufficient to maintain remission of symptoms.
Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
Storage
Store in a cool, dry place at a controlled room temperature not exceeding 77°F. Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
The appearance and severity of side effects with Temaril-P are dose-related and are minimal at the recommended dosage level.
The most common side effect of this medication is drowsiness, which typically decreases after it is given consistently over time.
Other possible side effects include (but may not be limited to) increased thirst, urination, and/or appetite; dull/dry haircoat; weight changes; excessive panting; GI effects (vomiting, diarrhea, GI ulceration); muscle wasting; weakness, muscle tremors, or rigidity; and behavioral changes (e.g., depression, restlessness, aggression).
Many side effects of corticosteroids are linked to high doses or prolonged usage; however, side effects may still occur during short-term therapy. Your veterinarian may provide specific instructions to help avoid or lessen these effects.
Contact your veterinarian immediately if your pet has complete loss of appetite, atypically low energy levels, extreme behavioral changes (e.g., aggression), bloody vomit, black or tarry stools, or shows any signs of infection (e.g., fever, chills).
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
Do NOT discontinue this medication abruptly; prolonged treatment with Temaril-P must be withdrawn gradually. Please consult your veterinarian before making any changes to the prescribed dosing schedule.
Do NOT use Temaril-P in animals with untreated Cushing’s disease, tuberculosis, active GI (peptic) or corneal ulcers, a current fungal infection, that are dehydrated, or those that are currently taking other anti-inflammatory drugs (e.g., aspirin, NSAIDs).
Use with caution in dogs with preexisting epilepsy/seizure disorders; diabetes; heart, liver, or kidney disease; or a current systemic infection. Steroid medications should be used with caution in young, growing animals, as prolonged use may stunt growth.
Use with extreme caution in pregnant animals. Safe use of this medication has not been established and may not be recommended in breeding or lactating animals. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to any phenothiazine or corticosteroid drug, including this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
The following drugs* may have potential interactions with this medication: antidiabetic agents (including insulins), aspirin, blood pressure medications (e.g., amlodipine, enalapril, telmisartan), azole antifungals (e.g., itraconazole, ketoconazole), CNS depressant drugs (e.g., hydroxyzine, methocarbamol, opioids), cyclosporine, digoxin, estriol, fluoroquinolone antibiotics (e.g., ciprofloxacin), metoclopramide, NSAIDs, ondansetron, phenobarbital, potassium-depleting diuretics (e.g., furosemide, hydrochlorothiazide), and SSRIs (e.g., fluoxetine, sertraline).
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 7/30/2025
-
Description
Product detailsTemaril-P (trimeprazine with prednisolone) is indicated for the relief of allergic itch and its associated inflammation, as well as itch resulting from atopic dermatitis and otitis in dogs. Its synergistic combination of antihistamine and corticosteroid may allow for lower doses of corticosteroids.1 Additionally, it’s found to be an effective therapy in various cough conditions, including “kennel cough,” allergic bronchitis, and other coughs of nonspecific origins. This oral tablet is given daily as prescribed by your vet.- Three-in-One Therapy: Prescription, oral tablet combines the anti-itch and anti-cough properties of trimeprazine with the anti-inflammatory qualities of prednisolone for a triple therapeutic effect in dogs.
- Multi-Purpose Treatment: Relieves itch and reduces inflammation from allergic & atopic dermatitis, and otitis. It also provides relief from coughing due to “kennel cough,” allergic bronchitis, and other nonspecific forms.
- Powerful & Effective: May relieve itching that doesn’t respond to other treatments.
- Simple Dosing: Twice-daily dosing administered orally as prescribed by your veterinarian.
References:1. Paradis M, Scott DW, Giroux D. Further investigations on the use of nonsteroidal and steroidal anti-inflammatory agents in the management of canine pruritus. J Am Anim Hosp Assoc. 1991;27:44-48.*Please note: The images provided are for illustrative purposes. Your product may be delivered in a Vetsource Pharmacy vial; product packaging & appearance may vary and are subject to manufacturer availability.Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogsActive ingredient(s)Trimeprazine tartrate, PrednisoloneInactive ingredientsComplete inactive ingredients list not provided by manufacturer.Brand nameTemaril-PDrug classPhenothiazine antihistamine, GlucocorticoidManufacturerZoetisProduct strength & sizeEach Temaril-P tablet contains 5 mg of trimeprazine and 2 mg of prednisolone. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.For current availability, please refer to the product selection above.UsageFollow your veterinarian’s instructions as prescribed.Manufacturer Dosage and Administration:Up to 10 lbs. – 1/2 (one-half) tablet, twice daily11-20 lbs. – 1 tablet, twice daily21-40 lbs. – 2 tablets, twice dailyOver 40 lbs. – 3 tablets, twice dailyAfter four days, reduce dosage to 1/2 (half) of the initial dose or to an amount just sufficient to maintain remission of symptoms.Missed dosesAdminister the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.StorageStore in a cool, dry place at a controlled room temperature not exceeding 77°F. Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsThe appearance and severity of side effects with Temaril-P are dose-related and are minimal at the recommended dosage level.The most common side effect of this medication is drowsiness, which typically decreases after it is given consistently over time.Other possible side effects include (but may not be limited to) increased thirst, urination, and/or appetite; dull/dry haircoat; weight changes; excessive panting; GI effects (vomiting, diarrhea, GI ulceration); muscle wasting; weakness, muscle tremors, or rigidity; and behavioral changes (e.g., depression, restlessness, aggression).Many side effects of corticosteroids are linked to high doses or prolonged usage; however, side effects may still occur during short-term therapy. Your veterinarian may provide specific instructions to help avoid or lessen these effects.Contact your veterinarian immediately if your pet has complete loss of appetite, atypically low energy levels, extreme behavioral changes (e.g., aggression), bloody vomit, black or tarry stools, or shows any signs of infection (e.g., fever, chills).Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.PrecautionsDo NOT discontinue this medication abruptly; prolonged treatment with Temaril-P must be withdrawn gradually. Please consult your veterinarian before making any changes to the prescribed dosing schedule.Do NOT use Temaril-P in animals with untreated Cushing’s disease, tuberculosis, active GI (peptic) or corneal ulcers, a current fungal infection, that are dehydrated, or those that are currently taking other anti-inflammatory drugs (e.g., aspirin, NSAIDs).Use with caution in dogs with preexisting epilepsy/seizure disorders; diabetes; heart, liver, or kidney disease; or a current systemic infection. Steroid medications should be used with caution in young, growing animals, as prolonged use may stunt growth.Use with extreme caution in pregnant animals. Safe use of this medication has not been established and may not be recommended in breeding or lactating animals. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.Do not administer to animals with a known history or suspected allergy/hypersensitivity to any phenothiazine or corticosteroid drug, including this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.Drug and food interactionsThe following drugs* may have potential interactions with this medication: antidiabetic agents (including insulins), aspirin, blood pressure medications (e.g., amlodipine, enalapril, telmisartan), azole antifungals (e.g., itraconazole, ketoconazole), CNS depressant drugs (e.g., hydroxyzine, methocarbamol, opioids), cyclosporine, digoxin, estriol, fluoroquinolone antibiotics (e.g., ciprofloxacin), metoclopramide, NSAIDs, ondansetron, phenobarbital, potassium-depleting diuretics (e.g., furosemide, hydrochlorothiazide), and SSRIs (e.g., fluoxetine, sertraline).*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 7/30/2025 -
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