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Trifexis for Dogs
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Elanco Animal Health

Trifexis for Dogs

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This item requires prescription approval.

$23.28 - $160.88
UPC:
727804562267
Source:
Vetsource
Product Type:
Medication
Ship Class:
default
Subscription Recurring Discount:
5
Health Benefit:
Flea, Tick & Heartworm
auto-order-discount:
8
auto-order:
true
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Product Information
Product details
Trifexis for Dogs is a beef-flavored tablet that kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections in dogs and puppies 8 weeks of age and older, weighing at least 5 pounds.
  • Trifexis delivers 5-in-1 protection from heartworms, fleas, & 3 more intestinal parasites in dogs 8 weeks of age or older and 5 pounds of body weight or greater.
  • Starts killing fleas in 30 minutes and kills 100% of adult fleas within 4 hours
  • Prevents heartworm disease and treats & controls roundworms, hookworms, & whipworms
  • Tasty, beef-flavored tablet for easy dosing
  • Protecting dogs from parasites for nearly 10 years, 272 million doses distributed (Elanco Animal Health, data on file)

Get fast-acting parasite protection for your dog in just one tablet every month. Trifexis not only prevents heartworm disease in dogs, but also treats and controls intestinal worms including roundworms, whipworms, and hookworms. Trifexis also delivers fast-acting flea treatment and flea infestation prevention, starting to kill fleas within 30 minutes of application and killing 100% of fleas on your dog within just 4 hours. It’s no surprise why Trifexis has been protecting dogs from parasites for nearly 10 years with more than 272 million doses distributed.*

When untreated, intestinal worms and fleas can cause serious symptoms and major discomfort for your dog. Intestinal worms are common parasites – even for indoor dogs – and can cause vomiting, weight loss and diarrhea. And flea bites aren’t just painful, they can cause serious skin issues and spread disease. That’s why Trifexis makes protecting your dog easy. Packing triple parasite protection into a single, once-a-month, beef-flavored tablet delivers the ultimate convenience in care. No need for greasy topical applications or flea collars. Check the product label for information on application and potential side effects.

Dogs must be at least eight weeks old to use Trifexis, with five available weight-based formulations for dogs weighing as little as 5 lbs. and up to 120 lbs.

Trifexis is only available by prescription. Subscribe to regular doorstep deliveries of Trifexis 6-dose packs so you never miss a monthly treatment. Before starting any heartworm prevention program, it’s important for your veterinarian to test your dog for an existing heartworm infection. At your next visit, tell your veterinarian you want the convenience of triple parasite protection for your dog so you can enjoy peace of mind from the backyard to the dog park.

Trifexis is a trademark of Elanco or its affiliates.
*Elanco Animal Health, data on file

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.



For
Dogs (8 weeks of age and older)

Active ingredient(s)
Milbemycin oxime, Spinosad

Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.

Brand name
Trifexis for Dogs

Drug class
Milbemycin antiparasitic, Spinosyn insecticide

Product flavoring
Trifexis for Dogs is “beef” flavored.
*Contains pork, hydrolyzed soy (does not contain actual beef)

Manufacturer
Elanco

Product strength & size
Weight Range Spinosad (per tablet) Milbemycin oxime (per tablet) Tablets administered
5 to 10 lbs 140 mg 2.3 mg One
10.1 to 20 lbs 270 mg 4.5 mg One
20.1 to 40 lbs 560 mg 9.3 mg One
40.1 to 60 lbs 810 mg 13.5 mg One
60.1 to 120 lbs 1620 mg 27 mg One

*For dogs over 120 lbs, administer the appropriate combination of tablets to cover your pet’s body weight.



Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.

Trifexis should be given orally at monthly intervals year-round, or as otherwise directed by your veterinarian.

Manufacturer Dosage and Administration:
Trifexis is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes.

Administer Trifexis with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of Trifexis with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.

Missed doses
If a dose is missed: give Trifexis immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.
Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.



Side effects
Trifexis is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, excessive salivation/drooling, itching, skin reactions (e.g., dermatitis), trembling, lethargy, and skin or ear reddening.

Contact your veterinarian immediately if your pet experiences a shock-like reaction, severe or persistent vomiting, or if you notice your pet has a seizure, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.

Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert.

For use in dogs only- not for human use. Keep this and all drugs out of the reach of children.
Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of Trifexis.

Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.
Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Trifexis is not effective against adult D. immitis. While the number of circulating microfilariae may decrease following treatment, Trifexis is not indicated for microfilariae clearance.
Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.
Use with caution in breeding females. The safe use of this medication has not been established and should be used with caution in breeding males and pregnant or nursing animals. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
Use with caution in dogs with a preexisting seizure disorder (e.g., epilepsy).
Puppies less than 14 weeks of age may experience a higher rate of vomiting.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Drug and food interactions
There are no documented drug or food interactions with Trifexis.
Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.

Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.

Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.


Last revised: 7/31/2025
  • Description

    Product details
    Trifexis for Dogs is a beef-flavored tablet that kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections in dogs and puppies 8 weeks of age and older, weighing at least 5 pounds.
    • Trifexis delivers 5-in-1 protection from heartworms, fleas, & 3 more intestinal parasites in dogs 8 weeks of age or older and 5 pounds of body weight or greater.
    • Starts killing fleas in 30 minutes and kills 100% of adult fleas within 4 hours
    • Prevents heartworm disease and treats & controls roundworms, hookworms, & whipworms
    • Tasty, beef-flavored tablet for easy dosing
    • Protecting dogs from parasites for nearly 10 years, 272 million doses distributed (Elanco Animal Health, data on file)

    Get fast-acting parasite protection for your dog in just one tablet every month. Trifexis not only prevents heartworm disease in dogs, but also treats and controls intestinal worms including roundworms, whipworms, and hookworms. Trifexis also delivers fast-acting flea treatment and flea infestation prevention, starting to kill fleas within 30 minutes of application and killing 100% of fleas on your dog within just 4 hours. It’s no surprise why Trifexis has been protecting dogs from parasites for nearly 10 years with more than 272 million doses distributed.*

    When untreated, intestinal worms and fleas can cause serious symptoms and major discomfort for your dog. Intestinal worms are common parasites – even for indoor dogs – and can cause vomiting, weight loss and diarrhea. And flea bites aren’t just painful, they can cause serious skin issues and spread disease. That’s why Trifexis makes protecting your dog easy. Packing triple parasite protection into a single, once-a-month, beef-flavored tablet delivers the ultimate convenience in care. No need for greasy topical applications or flea collars. Check the product label for information on application and potential side effects.

    Dogs must be at least eight weeks old to use Trifexis, with five available weight-based formulations for dogs weighing as little as 5 lbs. and up to 120 lbs.

    Trifexis is only available by prescription. Subscribe to regular doorstep deliveries of Trifexis 6-dose packs so you never miss a monthly treatment. Before starting any heartworm prevention program, it’s important for your veterinarian to test your dog for an existing heartworm infection. At your next visit, tell your veterinarian you want the convenience of triple parasite protection for your dog so you can enjoy peace of mind from the backyard to the dog park.

    Trifexis is a trademark of Elanco or its affiliates.
    *Elanco Animal Health, data on file

    Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.



    For
    Dogs (8 weeks of age and older)

    Active ingredient(s)
    Milbemycin oxime, Spinosad

    Inactive ingredients
    Complete inactive ingredients list not provided by manufacturer.

    Brand name
    Trifexis for Dogs

    Drug class
    Milbemycin antiparasitic, Spinosyn insecticide

    Product flavoring
    Trifexis for Dogs is “beef” flavored.
    *Contains pork, hydrolyzed soy (does not contain actual beef)

    Manufacturer
    Elanco

    Product strength & size
    Weight Range Spinosad (per tablet) Milbemycin oxime (per tablet) Tablets administered
    5 to 10 lbs 140 mg 2.3 mg One
    10.1 to 20 lbs 270 mg 4.5 mg One
    20.1 to 40 lbs 560 mg 9.3 mg One
    40.1 to 60 lbs 810 mg 13.5 mg One
    60.1 to 120 lbs 1620 mg 27 mg One

    *For dogs over 120 lbs, administer the appropriate combination of tablets to cover your pet’s body weight.



    Usage
    *For complete product information, please review the full prescribing information in the manufacturer package insert.

    Trifexis should be given orally at monthly intervals year-round, or as otherwise directed by your veterinarian.

    Manufacturer Dosage and Administration:
    Trifexis is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes.

    Administer Trifexis with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of Trifexis with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.

    Missed doses
    If a dose is missed: give Trifexis immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.
    If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

    Storage
    Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.
    Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.



    Side effects
    Trifexis is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, excessive salivation/drooling, itching, skin reactions (e.g., dermatitis), trembling, lethargy, and skin or ear reddening.

    Contact your veterinarian immediately if your pet experiences a shock-like reaction, severe or persistent vomiting, or if you notice your pet has a seizure, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).

    Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
    If you notice anything unusual, please consult your veterinarian.

    Precautions
    *For complete product information including warnings and precautions, please refer to the manufacturer package insert.

    For use in dogs only- not for human use. Keep this and all drugs out of the reach of children.
    Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of Trifexis.

    Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.
    Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Trifexis is not effective against adult D. immitis. While the number of circulating microfilariae may decrease following treatment, Trifexis is not indicated for microfilariae clearance.
    Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.
    Use with caution in breeding females. The safe use of this medication has not been established and should be used with caution in breeding males and pregnant or nursing animals. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
    Use with caution in dogs with a preexisting seizure disorder (e.g., epilepsy).
    Puppies less than 14 weeks of age may experience a higher rate of vomiting.

    Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
    If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

    Drug and food interactions
    There are no documented drug or food interactions with Trifexis.
    Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

    Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

    Adverse reactions
    If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.

    Overdose
    If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

    For humans:
    The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

    For animals:
    The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
    Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

    *Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.

    Disclaimer
    The content provided on this page is NOT medical advice.
    All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
    Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.


    Last revised: 7/31/2025
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