Altren Solution

Altren® Solution

Altren® Solution is an oral progestin used to suppress estrus in mares to allow for a predictable occurrence of estrus following drug withdrawal or maintain pregnancy in those that are progestin deficient. 

Horses

Altrenogest

Altren®, Regu-Mate® 

Oral Progestin

Aurora Pharmaceuticals, Inc

Altren® 0.22% Solution 150 ml: yellow (colorless to yellow) oil suspension. (NDC 51072-0085-01)

Altrenogest

Altren® Solution should be given to your horse as directed by your veterinarian. Wear vinyl, neoprene, or nitrile gloves when handling this medication to reduce potential for exposure. While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. Remove cover from bottle dispensing tip and connect luer lock syringe (without needle). Draw out appropriate volume of Altren® solution. Note: Do not remove syringe while bottle is inverted as spillage may result.

Administer solution directly on the base of the mare’s tongue or on the mare’s usual grain ration. Replace cover on bottle dispensing tip to prevent leakage. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary. Leur lock syringes are purchased separately.  Please ask your veterinarian for a recommendation for the correct syringe sizes.

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.

Avoid use in mares with chronic uterine infections. Side effects may occur. If you notice anything unusual, contact your veterinarian.

The following drugs can potentially interact with altrenogest: dinoprost, hypoglycemic agents, phenobarbital, and rifampin. Contact your veterinarian if your horse experiences any unusual reactions when different medications are given together.

Make sure to tell your veterinarian what other medication you are giving your horse. Quite often your veterinarian may prescribe two different medications, and a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your horse more closely. 

Not for use in humans. Keep out of reach of children. Avoid skin contact. Altren® is absorbed through unbroken skin, and exposure may result in serious side effects to both women and men. Wear vinyl, neoprene, or nitrile gloves when handling or administering Altren®, or when touching contaminated surfaces or equipment. Latex gloves are not protective.

Accidental absorption, such as via direct contact with the skin, could lead to a disruption of the menstrual cycle or prolongation of pregnancy. Immediately wash off accidental spillage on the skin with soap and water. Any equipment or surfaces that come in contact with Altren® should be adequately cleaned and decontaminated to prevent human exposure (see Reported HUMAN Effects from Exposure).

PEOPLE WHO SHOULD NOT HANDLE Altren®: Women who are or may be pregnant. Anyone with blood clots or clotting disorders, or with a history of these events. Anyone with a history of heart disease or stroke. Women with known or suspected breast cancer. People with known or suspected estrogen-dependent cancer. Women with vaginal bleeding of unknown cause. People with tumors which developed during the use of oral contraceptives or other estrogen-containing products. Anyone with liver dysfunction or disease.

Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your horse has any known drug sensitivities or allergies. If your horse displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; widespread hives and itching.

Adverse Reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Aurora Pharmaceutical at 888-215-1256 or Vetsource customer service at 877-738-4443.

Store at or below 77°F in controlled room temperature. Store upright and keep tightly closed. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.