Product details
Fludrocortisone is a mineralocorticoid (steroid) medication used to treat hypoadrenocorticism (Addison’s disease) in small animals.
This product is a tablet formulation.
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Used to treat hypoadrenocorticism (Addison’s disease) in dogs and cats.
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Corticosteroids should not be used concurrently with NSAIDs due to increased risk of gastrointestinal ulcers, perforation, and/or bleeding.
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Do not use this medication during pregnancy or in animals that have an active systemic fungal infection.
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May be prescribed for other animal species; please consult your veterinarian.
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While this drug does not have an FDA-approved indication for all animal uses, it is commonly accepted for veterinarians to prescribe this medication for use in animals.
*Please note: This is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs and Cats
Active ingredient(s)
Fludrocortisone acetate
Common brand names
Florinef
Drug class
Mineralocorticoid
Product strength & size
This product contains 0.1 mg of fludrocortisone acetate in each tablet. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
Fludrocortisone Tablets should be given orally as directed by your veterinarian.
Do not discontinue this medication abruptly. Please consult your veterinarian before making any changes to the prescribed dosing schedule and contact your veterinarian ahead of time if your pet needs a refill.
This medication can be given with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.
Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F, brief excursions permitted between 59 and 86°F). Avoid excessive heat. Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
Side effects are generally considered unlikely/uncommon with this medication and are often associated with chronically high doses or abrupt discontinuation.
The most common side effects of this medication are vomiting, excessive thirst and/or urination, increased appetite, and panting.
Other possible side effects include, but may not be limited to, the effects listed below. Contact your veterinarian immediately if you notice anything unusual, including:
If the dose is too high: dull/dry haircoat, hair loss, swelling, weight gain, high blood pressure, and weakness.
If the dose is too low: lowered mood or energy level, decreased appetite, weight loss, vomiting, diarrhea, weakness/collapse.
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
Precautions
Do NOT discontinue this medication abruptly. Your veterinarian will provide specific instructions for stopping this medication if needed.
Do NOT use this medication during pregnancy or in animals that have an active systemic fungal infection.
Use with caution in animals with congestive heart failure (CHF), severe kidney disease, or edema (swelling/fluid retention).
Steroid medications can weaken your pet's immune system, making it easier for them to get an infection (or worsen an existing one). Vaccines may not be recommended while your pet is taking this medication.
Safe use of this medication has not been established and may not be recommended in breeding or lactating animals. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to any corticosteroid drug, including this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
The following drugs* may have potential interactions with this medication: aspirin, antidiabetic agents (including insulins), azole antifungals (e.g., ketoconazole), beta blockers (e.g., atenolol, sotalol), blood pressure medications (e.g., enalapril, telmisartan), calcium channel blockers (e.g., amlodipine, diltiazem), concurrent corticosteroids (e.g., dexamethasone, prednisone), cyclosporine, digoxin, diuretics (e.g., furosemide, hydrochlorothiazide, spironolactone), fluoroquinolone antibiotics (e.g., ciprofloxacin), NSAIDs, phenobarbital, praziquantel, and warfarin.
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 7/02/2025