Heartgard PLUS Chewables

HEARTGARD Plus (ivermectin/pyrantel) Chewables for Dogs are the only real-beef chews that prevent heartworm disease and treat and control hookworm and roundworm infections.

HEARTGARD Plus (ivermectin/pyrantel) Chewables for Dogs are the #1 vet-recommended¹ protection against heartworm disease – an invisible threat that can be caused by just one bite from an infected mosquito and can lead to permanent damage in less than three months.² HEARTGARD Plus chews also treat and control 3 species of hookworms and 2 species of roundworms in dogs, which are among the most prevalent intestinal nematode parasites.³ With cases in all 50 states, it’s important to protect your dog with a monthly heartworm preventive year-round.³ Following the use of HEARTGARD Plus chews, digestive and neurologic side effects have been reported.

HEARTGARD Plus chews are also #1 dog-preferred⁴, making the tasty, Real-Beef chew easy to give your dog for heartworm disease prevention. HEARTGARD Plus is safe to use in all dogs aged 6 weeks and older. Year-round monthly dosing is recommended by the American Heartworm Society as an easy way to protect your dog throughout the year. Ask your veterinarian about preventing heartworm disease in your dog with HEARTGARD Plus chews, and make sure they have a current annual heartworm test result on file.

References:

1. Data on file at Boehringer Ingelheim

2. Current Canine Guidelines for Prevention, Diagnosis, and Management of Heartworm (Dirofilaria immitis) Infection in Dogs. American Heartworm Society.

3. Heartworm Parasite Prevalence Maps. Companion Animal Parasite Council. https://capcvet.org/maps/#/2022/all-year/heartworm-canine/dog/united-states. Accessed April 20, 2022.

4. Data on file at Boehringer Ingelheim

5. Data on file at Boehringer Ingelheim

6. HEARTGARD Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.

Dogs (6 weeks of age and older)

Ivermectin, Pyrantel pamoate

Complete inactive ingredients list not provided by manufacturer.

HEARTGARD Plus

Avermectin antiparasitic, Tetrahydropyrimidine anthelmintic

HEARTGARD Plus Chewables are beef flavored.

Boehringer Ingelheim Animal Health USA

Dog weight	Chews per month	Ivermectin content	Pyrantel content	Color (foil & carton)
0 to 25 lbs	One	68 mcg	57 mg	Blue
26 to 50 lbs	One	136 mcg	114 mg	Green
51 to 100 lbs	One	272 mcg	227 mg	Brown

*For dogs over 100 lbs, administer the appropriate combination of chewables to cover your pet’s body weight.

*For complete product information, please review the full prescribing information in the manufacturer package insert.

Manufacturer recommended usage:

HEARTGARD Plus (ivermectin/pyrantel) should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight.

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus (ivermectin/pyrantel) palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

If a dose is missed: give HEARTGARD Plus immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Store in a cool, dry place at a controlled room temperature (68 to 77°F, brief excursions permitted between 59 and 86°F). Protect from light. Keep this medication in its original packaging and out of the reach of children and pets. Store away from heat and direct sunlight.

Only remove 1 tablet at a time from the foil-backed blister card and return the card to the box to protect from light. Tablets should remain sealed and only taken out of the blister pack at the time of dosing.

Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

HEARTGARD Plus Chewables are generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting and diarrhea.

Other reported side effects include (but may not be limited to) decreased appetite, depression/lethargy, hypersalivation (drooling), and pupil dilation.

Contact your veterinarian immediately if your pet experiences severe/excessive drooling, seizures or tremors, or exhibits decreased coordination (e.g., staggering, stumbling, difficulty walking).

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

*For complete product information including warnings and precautions, please refer to the manufacturer package insert.

All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD PLUS, which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD PLUS.

Choking or intestinal obstruction has been reported after dosing with HEARTGARD PLUS. For dogs that normally swallow treats whole, chewables may be broken into pieces.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to any avermectin or tetrahydropyrimidine drug, including this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

There are no documented drug or food interactions with this medication when given at the recommended dosage.

Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Boehringer Ingelheim Animal Health USA at 1-888-637-4251 or Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.