Product details
NexGard PLUS is a soft, beef-flavored chewable tablet administered once a month to protect your dog from fleas, ticks, heartworm disease, roundworms, and hookworms.
- Convenient, One-And-Done monthly parasite protection for your dog
- Provides flea and tick protection for dogs
- Kills adult fleas and 5 species of ticks
- Prevents heartworm disease by eliminating heartworm larvae before they can grow into adults and cause heartworm disease
- Treats and controls 3 species of hookworms and 2 species of roundworms
NexGard PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is available in five sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. One monthly dose delivers a full 30 days of protection from fleas, ticks, heartworm disease, roundworms, and hookworms. NexGard PLUS is approved for puppies from 8 weeks of age and weighing 4 lbs. or more.
NexGard PLUS is approved for prevention of Lyme infections as a direct result of killing black-legged ticks (Ixodes scapularis).
Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs (8 weeks of age and older)
Active ingredient(s)
Afoxolaner, Moxidectin, Pyrantel pamoate
Inactive ingredients
Inactive ingredients list not provided by manufacturer.
Brand name
NexGard PLUS
Drug class
Isoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Tetrahydropyrimidine anthelmintic
Product flavoring
NexGard PLUS chewable tablets are beef-flavored.
*Contains soy; NexGard PLUS chews are gluten-free and do not contain actual beef.
Manufacturer
Boehringer Ingelheim Animal Health USA
Product strength & size
| Weight Range | Afoxolaner (per tablet) | Moxidectin (per tablet) | Pyrantel (per tablet) |
|---|---|---|---|
| 4 to 8 lbs | 9.375 mg | 45 mcg | 18.75 mg |
| 8.1 to 17 lbs | 18.75 mg | 90 mcg | 37.5 mg |
| 17.1 to 33 lbs | 37.5 mg | 180 mcg | 75 mg |
| 33.1 to 66 lbs | 75 mg | 360 mcg | 150 mg |
| 66.1 to 132 lbs | 150 mg | 720 mcg | 300 mg |
*For dogs over 132 lbs., administer the appropriate combination of chewable tablets to cover your pet’s body weight.
Usage
*See enclosed insert for complete manufacturer dosage and administration recommendations*
NexGard PLUS should be given orally as directed by your veterinarian.
This medication can be given with or without food. Care should be taken to ensure that your dog consumes the complete dose, and that part of the dose is not lost or refused.
This medication should be administered to your dog year-round at monthly (every 30 day) intervals for continuous protection from heartworm disease, fleas, ticks, roundworms, and hookworms. For dogs over 132 lbs., administer the appropriate combination of tablets to ensure complete protection.
For heartworm disease prevention, NexGard PLUS should be given once monthly for at least six months after the dog’s last exposure to mosquitoes.
Remove only 1 tablet at a time from the foil-backed blister card and return the card to the box to protect from light. Tablets should remain sealed and only taken out of the blister pack at the time of dosing.
Missed doses
If a dose is missed: give NexGard PLUS immediately to resume monthly dosing and consult your veterinarian. Do not give two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.
Storage
Store in a cool, dry place at a controlled room temperature (at or below 77°F, with excursions permitted up to 104°F). Keep this medication in its original packaging and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
NexGard PLUS is generally well tolerated, and side effects are uncommon when given at the usual dosage. The most frequently reported side effects include diarrhea, vomiting, lethargy, and itching.
Use with caution in dogs with a history of seizures or neurologic disorders. Contact your veterinarian immediately if your pet has a seizure after taking this medication.
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*See product packaging/insert for complete product details including warnings and precautions.
For oral use in dogs only- not for use in humans. Keep this and all drugs in a secure location out of the reach of children and animals to prevent accidental ingestion or overdose.
Afoxolaner, one of the ingredients in NexGard PLUS, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
Prior to administration of NexGard PLUS, dogs should be tested for existing heartworm infections.
The safe use of NexGard PLUS in breeding, pregnant, or lactating dogs has not been evaluated.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.
Drug and food interactions
There are no documented drug or food interactions with NexGard PLUS.
Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Boehringer Ingelheim Animal Health USA at 1-888-637-4251 or Vetsource Pet Owner Care at 877-738-4443.
Last revised: 5/19/2025
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Description
Product detailsNexGard PLUS is a soft, beef-flavored chewable tablet administered once a month to protect your dog from fleas, ticks, heartworm disease, roundworms, and hookworms.- Convenient, One-And-Done monthly parasite protection for your dog
- Provides flea and tick protection for dogs
- Kills adult fleas and 5 species of ticks
- Prevents heartworm disease by eliminating heartworm larvae before they can grow into adults and cause heartworm disease
- Treats and controls 3 species of hookworms and 2 species of roundworms
NexGard PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is available in five sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. One monthly dose delivers a full 30 days of protection from fleas, ticks, heartworm disease, roundworms, and hookworms. NexGard PLUS is approved for puppies from 8 weeks of age and weighing 4 lbs. or more.NexGard PLUS is approved for prevention of Lyme infections as a direct result of killing black-legged ticks (Ixodes scapularis).Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs (8 weeks of age and older)Active ingredient(s)Afoxolaner, Moxidectin, Pyrantel pamoateInactive ingredientsInactive ingredients list not provided by manufacturer.Brand nameNexGard PLUSDrug classIsoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Tetrahydropyrimidine anthelminticProduct flavoringNexGard PLUS chewable tablets are beef-flavored.*Contains soy; NexGard PLUS chews are gluten-free and do not contain actual beef.ManufacturerBoehringer Ingelheim Animal Health USAProduct strength & sizeWeight Range Afoxolaner (per tablet) Moxidectin (per tablet) Pyrantel (per tablet) 4 to 8 lbs 9.375 mg 45 mcg 18.75 mg 8.1 to 17 lbs 18.75 mg 90 mcg 37.5 mg 17.1 to 33 lbs 37.5 mg 180 mcg 75 mg 33.1 to 66 lbs 75 mg 360 mcg 150 mg 66.1 to 132 lbs 150 mg 720 mcg 300 mg *For dogs over 132 lbs., administer the appropriate combination of chewable tablets to cover your pet’s body weight.Usage*See enclosed insert for complete manufacturer dosage and administration recommendations*NexGard PLUS should be given orally as directed by your veterinarian.This medication can be given with or without food. Care should be taken to ensure that your dog consumes the complete dose, and that part of the dose is not lost or refused.This medication should be administered to your dog year-round at monthly (every 30 day) intervals for continuous protection from heartworm disease, fleas, ticks, roundworms, and hookworms. For dogs over 132 lbs., administer the appropriate combination of tablets to ensure complete protection.For heartworm disease prevention, NexGard PLUS should be given once monthly for at least six months after the dog’s last exposure to mosquitoes.Remove only 1 tablet at a time from the foil-backed blister card and return the card to the box to protect from light. Tablets should remain sealed and only taken out of the blister pack at the time of dosing.Missed dosesIf a dose is missed: give NexGard PLUS immediately to resume monthly dosing and consult your veterinarian. Do not give two doses at once.If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.StorageStore in a cool, dry place at a controlled room temperature (at or below 77°F, with excursions permitted up to 104°F). Keep this medication in its original packaging and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsNexGard PLUS is generally well tolerated, and side effects are uncommon when given at the usual dosage. The most frequently reported side effects include diarrhea, vomiting, lethargy, and itching.Use with caution in dogs with a history of seizures or neurologic disorders. Contact your veterinarian immediately if your pet has a seizure after taking this medication.Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*See product packaging/insert for complete product details including warnings and precautions.For oral use in dogs only- not for use in humans. Keep this and all drugs in a secure location out of the reach of children and animals to prevent accidental ingestion or overdose.Afoxolaner, one of the ingredients in NexGard PLUS, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.Prior to administration of NexGard PLUS, dogs should be tested for existing heartworm infections.The safe use of NexGard PLUS in breeding, pregnant, or lactating dogs has not been evaluated.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.Drug and food interactionsThere are no documented drug or food interactions with NexGard PLUS.Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Boehringer Ingelheim Animal Health USA at 1-888-637-4251 or Vetsource Pet Owner Care at 877-738-4443.Last revised: 5/19/2025 -
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