Product Information

Description

Product details

Pentoxifylline ER (extended-release) is an immunomodulatory medication used to treat a variety of immune-mediated skin conditions, reduce inflammation, and improve blood flow in dogs, cats, and horses.

Used to treat various conditions in dogs including vasculitis, atopic or contact dermatitis, and cutaneous lupus
Can be used to help treat navicular disease, endotoxemia, and certain other autoimmune skin conditions in horses
Although less common, pentoxifylline may be prescribed for cats to treat certain skin conditions or to reduce blood vessel inflammation.
Follow your veterinarian's instructions; splitting tablets may be necessary to accurately dose smaller animals, but tablets should NOT be crushed.
May be used for other animal species; please consult your veterinarian.

While this medication does not have an FDA-approved indication for animal use, it is a common and acceptable practice for veterinarians to prescribe this human medication for use in animals.

*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.

Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For

Dogs, Cats, and Horses

Active ingredient(s)

Pentoxifylline (extended-release)

Common brand names

Trental®

Drug class

Hemorrheologic, Immunomodulatory agent

Product strength & size

This product is available in 400 mg extended-release tablets; please select the appropriate option for your pet as recommended by your veterinarian.

For current availability, please refer to the product selection above.

Usage

Pentoxifylline ER should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.

Although extended-release tablets are generally not designed to be split, it is acceptable to do so for this medication when recommended by your veterinarian. Splitting these tablets may be recommended when precise dosing for smaller animals is required.

Tablets should NOT be crushed, as this may potentially increase the risk of adverse effects.

This medication should be given with food.

Missed doses

Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.

Storage

Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Side effects

This medication is usually well-tolerated, and side effects are considered uncommon. Reported side effects include (but may not be limited to): appetite loss, vomiting, diarrhea, and nervousness or excitement.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

Precautions

Do NOT use this medication in animals with active (or history of) bleeding in the brain or eyes.

Use with caution in animals with bleeding disorders, kidney or liver impairment, and those who are at risk for excessive bleeding.

Safe use of this medication has not been established in breeding, pregnant, or lactating animals.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to caffeine, theophylline, and this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.

Drug and food interactions

The following drugs* may have potential interactions with this medication: anticoagulants (e.g., warfarin), aspirin, blood pressure medications (e.g., amlodipine, enalapril, telmisartan), clopidogrel, insulins, and NSAIDs (e.g., deracoxib).

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.

Last revised: 4/23/2025

Description
Product details
Pentoxifylline ER (extended-release) is an immunomodulatory medication used to treat a variety of immune-mediated skin conditions, reduce inflammation, and improve blood flow in dogs, cats, and horses.
- Used to treat various conditions in dogs including vasculitis, atopic or contact dermatitis, and cutaneous lupus
- Can be used to help treat navicular disease, endotoxemia, and certain other autoimmune skin conditions in horses
- Although less common, pentoxifylline may be prescribed for cats to treat certain skin conditions or to reduce blood vessel inflammation.
- Follow your veterinarian's instructions; splitting tablets may be necessary to accurately dose smaller animals, but tablets should NOT be crushed.
- May be used for other animal species; please consult your veterinarian.
While this medication does not have an FDA-approved indication for animal use, it is a common and acceptable practice for veterinarians to prescribe this human medication for use in animals.

*Please note: this is a generic medication. Product packaging and appearance, including size, color, and shape, may differ from the description or images provided and are subject to manufacturer availability.

Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For
Dogs, Cats, and Horses

Active ingredient(s)
Pentoxifylline (extended-release)

Common brand names
Trental®

Drug class
Hemorrheologic, Immunomodulatory agent

Product strength & size
This product is available in 400 mg extended-release tablets; please select the appropriate option for your pet as recommended by your veterinarian.
For current availability, please refer to the product selection above.

Usage
Pentoxifylline ER should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.
Although extended-release tablets are generally not designed to be split, it is acceptable to do so for this medication when recommended by your veterinarian. Splitting these tablets may be recommended when precise dosing for smaller animals is required.
Tablets should NOT be crushed, as this may potentially increase the risk of adverse effects.
This medication should be given with food.

Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.

Storage
Store in a cool, dry place at a controlled room temperature (68 to 77°F, excursions permitted between 59 and 86°F). Keep in a tight, light-resistant container and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Side effects
This medication is usually well-tolerated, and side effects are considered uncommon. Reported side effects include (but may not be limited to): appetite loss, vomiting, diarrhea, and nervousness or excitement.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.

Precautions
Do NOT use this medication in animals with active (or history of) bleeding in the brain or eyes.
Use with caution in animals with bleeding disorders, kidney or liver impairment, and those who are at risk for excessive bleeding.
Safe use of this medication has not been established in breeding, pregnant, or lactating animals.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to caffeine, theophylline, and this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.

Drug and food interactions
The following drugs* may have potential interactions with this medication: anticoagulants (e.g., warfarin), aspirin, blood pressure medications (e.g., amlodipine, enalapril, telmisartan), clopidogrel, insulins, and NSAIDs (e.g., deracoxib).
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.

Last revised: 4/23/2025
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