Simparica TRIO Chewables for Dogs

Simparica Trio is a pork liver-flavored chewable tablet administered once per month to protect your dog from heartworm disease, fleas, ticks, roundworms, and hookworms.

Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds, Simparica Trio begins working against fleas in just four hours and kills five types of ticks - including the deer tick that may cause Lyme disease. Just one tasty liver-flavored chew does the job of two or three parasite medications, and in a study nine out of 10 dogs ate Simparica Trio voluntarily.¹ It can be given with or without food. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Trust the #1 heartworm disease preventative chosen by veterinarians² and prescribed to over 7 million patients.³ Available by veterinarian prescription only. Ask your vet if Simparica Trio is right for your dog.

References:

1. Study A161C-US-15-634. Data on file. Zoetis Inc.

2. Heartworm Disease Preventative; DVM 360 ’22 Survey.

3. Kynetec Purchasing Data Vet Clinics Q3 QBR

Dogs (8 weeks of age and older)

Sarolaner, Moxidectin, Pyrantel pamoate

Inactive ingredients list not provided by manufacturer.

Simparica Trio

Isoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Tetrahydropyrimidine anthelmintic

Simparica Trio is a pork liver-flavored chewable tablet.

Zoetis

*For dogs over 132 lbs, administer the appropriate combination of tablets to cover your pet’s body weight.

Simparica Trio should be given orally as directed by your veterinarian.

This medication can be given with or without food. Care should be taken to ensure that your dog consumes the complete dose, and that part of the dose is not lost or refused.

This medication should be administered to your dog year-round at monthly (every 30 day) intervals for continuous protection from heartworm disease, fleas, ticks, roundworms, and hookworms. For dogs over 132 lbs, administer the appropriate combination of tablets to ensure complete protection.

Do NOT remove tablets from the foil blister pack until just before administration. The sealed blister pack should be kept in its original box/packaging for protection from environmental factors (e.g., light, moisture).

If a dose is missed: give Simparica Trio immediately to resume monthly dosing and consult your veterinarian. Do not give two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Store in a cool, dry place at a controlled room temperature (at or below 86°F). Keep this medication in its original packaging and out of the reach of children and pets. Store away from heat and direct sunlight. Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.

Simparica Trio is generally well tolerated in dogs, and there are very few side effects when given at the usual dosage. Reported side effects include (but may not be limited to): vomiting, diarrhea, lethargy, and loss of appetite.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

For oral use in dogs only- not for use in humans.

Sarolaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.

Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections.

The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.

There are no documented drug or food interactions with Simparica Trio.

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.