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Vetoryl (Trilostane) Capsules

This product requires a veterinary prescription.
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A Chemical on the Prop 65 List
Vetoryl® Capsules
Product Information
Vetoryl® Capsules is used to treat hyperadrenocorticism (Cushing's disease) in dogs. 
Generic Name
Brand Names
Drug Class
Adrenal Steroid Synthesis Inhibitor
Product Description & Form
Vetoryl® 5 mg Capsules 30 ct: 12 mm, white & black capsule, not scored, imprinted with VETORYL;5;mg. (NDC 17033-0105-30)
Vetoryl® 10 mg Capsules 30 ct: 14 mm, white & black capsule, not scored, imprinted with VETORYL;10;mg. (NDC 17033-0110-30)
Vetoryl® 20 mg Capsules 30 ct: 14 mm, white & black capsule, not scored, imprinted with VETORYL;20;mg. (NDC 17033-0111-30)
Vetoryl® 30 mg Capsules 30 ct: 16 mm, white & black capsule, not scored, imprinted with VETORYL;30;mg. (NDC 17033-0130-30)
Vetoryl® 60 mg Capsules 30 ct: 16 mm, white & black capsule, not scored, imprinted with VETORYL;60;mg. (NDC 17033-0160-30)
Vetoryl® 120 mg Capsules 30 ct: 16 mm, white & black capsule, not scored, imprinted with VETORYL;120;mg. (NDC 17033-0112-30)
  • Indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism (Cushing's disease and syndrome) in dogs
  • Blocks the excessive production of cortisol by reversibly inhibiting the action of the enzyme 3-ß hydroxysteroid dehydrogenase
  • While treatment with trilostane significantly reduces serum cortisol concentrations, it has not been found to reduce aldosterone significantly
Active Ingredients
Vetoryl® should be given orally as directed by your veterinarian. Best if given with food. 
Missed Doses
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
Side Effects
Side effects may include lethargy, vomiting, diarrhea, or loss of appetite.  
Other side effects may occur. If you notice any of these side effects, or anything unusual, contact your veterinarian immediately.
Drug & Food Interactions
The following drugs can potentially interact with trilostane: benazepril, enalapril, ketoconazole, potassium supplements, and spironolactone. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Make sure your veterinarian is aware of all medications and/or supplements you are giving to your pet. Quite often your veterinarian may prescribe two different medications even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
Do not use Vetoryl® in animals with primary hepatic disease or renal insufficiency. Do not use in pregnant dogs.
Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.
Adverse Reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Dechra at 866-933-2472 or Vetsource customer service at 877-738-4443.
Store at controlled room temperature (77°F), with excursions permitted between 59° to 86°F. Keep this medicine out of reach of children. Store in a childproof container. Store this medication in a cool, dry place away from heat and direct sunlight. Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
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Nutritional Info