Product details
Vetoryl Capsules (trilostane) are indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism (HAC) in dogs and can greatly reduce the clinical signs associated with Cushing’s syndrome, helping to restore your dog’s vitality.
- FDA-approved for the treatment of Pituitary-Dependent Hyperadrenocorticism (PDH) and Adrenal-Dependent Hyperadrenocorticism (ADH) in dogs.
- Vetoryl Capsules contain trilostane, an adrenal steroid synthesis inhibitor used to reduce circulating cortisol levels, leading to improvement in many of the clinical signs of HAC (Cushing’s disease).
- Provides flexible and accurate dosing with six strengths (5 mg, 10 mg, 20 mg, 30 mg, 60 mg, and 120 mg capsules).
- Do not use Vetoryl Capsules in pregnant dogs or those with primary hepatic disease or renal insufficiency; do not handle if you are pregnant or trying to conceive.
- Available in blister packs of 30 capsules.
Vetoryl is a prescription medication prescribed to aid in your dog's treatment of hyperadrenocorticism—also known as Cushing's disease. This medication treats both pituitary-dependent and adrenal-dependent cases and controls the excess production of cortisol caused by the disease.
This product contains a chemical on the Prop 65 List.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs
Active ingredient(s)
Trilostane
Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.
Brand name
Vetoryl Capsules
Drug class
Adrenal steroid synthesis inhibitor
Manufacturer
Dechra Veterinary Products
Product strength & size
Vetoryl Capsules may be available in multiple strengths and/or sizes. Please ensure the selected product is appropriate for your pet, as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.
Vetoryl Capsules for Dogs should be given orally as directed by your veterinarian. Wash your hands thoroughly with soap and water after handling the medication. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.
Vetoryl Capsules should be administered with food.
Capsules should be kept sealed in their original packaging until administration and should not be broken, split, or opened.
Your veterinarian may need to perform bloodwork and/or monitor your pet closely while taking this medication. Do not miss any follow-up visits.
Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.
Storage
Store in a cool, dry place at a controlled room temperature (77°F), with excursions permitted between 59 and 86°F. Keep the medication sealed in its original packaging and out of the reach of children and pets. Do not puncture foil and expose capsules until it is time for administration. Store away from heat and direct sunlight.
Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.
Side effects
Vetoryl is generally well tolerated in dogs. The most common side effects of this medication are an unexpected decrease in appetite, vomiting, diarrhea, and lethargy.
Discontinue Vetoryl Capsules and contact your veterinarian immediately if any signs of intolerance are observed, including vomiting, diarrhea, lethargy, poor/reduced appetite, weakness, or collapse.
A potentially life-threatening medical emergency known as an Addisonian crisis can occur if cortisol levels become critically low. Seek emergency veterinary care immediately if any signs of this are observed, including pale gums, weakness or collapse, or severe/bloody vomiting or diarrhea.
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert.
For oral use in dogs only- not for human use. Keep out of reach of children.
Wash hands after use. Do not empty capsule contents and do not attempt to divide the capsules. Do not handle the capsules if pregnant or if trying to conceive. Trilostane is associated with teratogenic effects and early pregnancy loss in laboratory animals. In the event of accidental ingestion/overdose, seek medical advice immediately and take the labeled container with you.
Do NOT use Vetoryl Capsules in animals with primary hepatic disease or renal insufficiency.
Do NOT use in pregnant dogs. Studies conducted with trilostane in laboratory animals have shown teratogenic effects and early pregnancy loss.
The safe use of this drug has not been evaluated in lactating dogs and males intended for breeding. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.
All dogs should undergo a thorough history and physical examination before initiation of therapy with Vetoryl Capsules.
Owners should be advised to discontinue therapy immediately and contact their veterinarian if signs of potential drug toxicity are observed.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
The following drugs* may have potential interactions with this medication:
ACE inhibitors (e.g., benazepril, enalapril), ARBs (e.g., telmisartan), ketoconazole, mitotane, potassium-sparing diuretics (e.g., spironolactone), potassium salts (e.g., potassium bromide, potassium citrate), and potassium supplements.
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Dechra Veterinary Products at 1-866-933-2472 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 8/07/2025
-
Description
Product detailsVetoryl Capsules (trilostane) are indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism (HAC) in dogs and can greatly reduce the clinical signs associated with Cushing’s syndrome, helping to restore your dog’s vitality.- FDA-approved for the treatment of Pituitary-Dependent Hyperadrenocorticism (PDH) and Adrenal-Dependent Hyperadrenocorticism (ADH) in dogs.
- Vetoryl Capsules contain trilostane, an adrenal steroid synthesis inhibitor used to reduce circulating cortisol levels, leading to improvement in many of the clinical signs of HAC (Cushing’s disease).
- Provides flexible and accurate dosing with six strengths (5 mg, 10 mg, 20 mg, 30 mg, 60 mg, and 120 mg capsules).
- Do not use Vetoryl Capsules in pregnant dogs or those with primary hepatic disease or renal insufficiency; do not handle if you are pregnant or trying to conceive.
- Available in blister packs of 30 capsules.
Vetoryl is a prescription medication prescribed to aid in your dog's treatment of hyperadrenocorticism—also known as Cushing's disease. This medication treats both pituitary-dependent and adrenal-dependent cases and controls the excess production of cortisol caused by the disease.This product contains a chemical on the Prop 65 List.Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogsActive ingredient(s)TrilostaneInactive ingredientsComplete inactive ingredients list not provided by manufacturer.Brand nameVetoryl CapsulesDrug classAdrenal steroid synthesis inhibitorManufacturerDechra Veterinary ProductsProduct strength & sizeVetoryl Capsules may be available in multiple strengths and/or sizes. Please ensure the selected product is appropriate for your pet, as recommended by your veterinarian.For current availability, please refer to the product selection above.Usage*For complete product information, please review the full prescribing information in the manufacturer package insert.Vetoryl Capsules for Dogs should be given orally as directed by your veterinarian. Wash your hands thoroughly with soap and water after handling the medication. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.Vetoryl Capsules should be administered with food.Capsules should be kept sealed in their original packaging until administration and should not be broken, split, or opened.Your veterinarian may need to perform bloodwork and/or monitor your pet closely while taking this medication. Do not miss any follow-up visits.Missed dosesAdminister the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give two doses at once.StorageStore in a cool, dry place at a controlled room temperature (77°F), with excursions permitted between 59 and 86°F. Keep the medication sealed in its original packaging and out of the reach of children and pets. Do not puncture foil and expose capsules until it is time for administration. Store away from heat and direct sunlight.Do not store in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsVetoryl is generally well tolerated in dogs. The most common side effects of this medication are an unexpected decrease in appetite, vomiting, diarrhea, and lethargy.Discontinue Vetoryl Capsules and contact your veterinarian immediately if any signs of intolerance are observed, including vomiting, diarrhea, lethargy, poor/reduced appetite, weakness, or collapse.A potentially life-threatening medical emergency known as an Addisonian crisis can occur if cortisol levels become critically low. Seek emergency veterinary care immediately if any signs of this are observed, including pale gums, weakness or collapse, or severe/bloody vomiting or diarrhea.Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the manufacturer package insert.For oral use in dogs only- not for human use. Keep out of reach of children.Wash hands after use. Do not empty capsule contents and do not attempt to divide the capsules. Do not handle the capsules if pregnant or if trying to conceive. Trilostane is associated with teratogenic effects and early pregnancy loss in laboratory animals. In the event of accidental ingestion/overdose, seek medical advice immediately and take the labeled container with you.Do NOT use Vetoryl Capsules in animals with primary hepatic disease or renal insufficiency.Do NOT use in pregnant dogs. Studies conducted with trilostane in laboratory animals have shown teratogenic effects and early pregnancy loss.The safe use of this drug has not been evaluated in lactating dogs and males intended for breeding. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.All dogs should undergo a thorough history and physical examination before initiation of therapy with Vetoryl Capsules.Owners should be advised to discontinue therapy immediately and contact their veterinarian if signs of potential drug toxicity are observed.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.Drug and food interactionsThe following drugs* may have potential interactions with this medication: ACE inhibitors (e.g., benazepril, enalapril), ARBs (e.g., telmisartan), ketoconazole, mitotane, potassium-sparing diuretics (e.g., spironolactone), potassium salts (e.g., potassium bromide, potassium citrate), and potassium supplements.*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Dechra Veterinary Products at 1-866-933-2472 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 8/07/2025 -
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