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Varenzin-CA1 Oral Suspension

This product requires a veterinary prescription.
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Varenzin™-CA1 Oral Suspension for Cats
Product Information
Varenzin™-CA1 Oral Suspension is a once-daily oral option that safely treats non-regenerative anemia in cats with chronic kidney disease (CKD).  
Generic Name
Molidustat sodium
Brand Names
Drug Class
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor
Product Flavoring
Varenzin™-CA1 Oral Suspension is fish oil flavored.
Product Description & Form
Varenzin™-CA1 Oral Suspension 27 ml: white to yellow-white oily suspension. (NDC 58198-3697-01)
  • FIRST and ONLY FDA conditionally approved option for the treatment of CKD-related anemia in cats
  • Stimulates a cat’s body to create its own erythropoietin 
  • Approved for convenient at-home treatment; no in-clinic injections needed
  • No refrigeration required
  • Features a mode of action that induces the genetic transcription of erythropoietin, increasing both erythropoietin and red blood cell production 
  • Once-daily, flavored oral solution
  • Specifically approved for use in cats with CKD
  • Dispensing system includes an oral dosing syringe with marks in 0.1 ml increments
  • Bottle is designed to treat a cat for 28 days
Active Ingredients
Molidustat sodium
Varenzin™-CA1 Oral Suspension should be given orally as directed by your veterinarian. May be given with or without food. Routine lab monitoring is recommended to evaluate effectiveness.
To administer Varenzin™-CA1 Oral Suspension: Shake well before using. Remove the cap. Use the enclosed syringe for each treatment. Place the syringe nozzle firmly into the opening of the bottle. Turn the bottle upside down and withdraw the necessary volume. Turn the bottle back into an upright position before removing the syringe. The product should be administered with the syringe into the cat’s mouth. See illustrations in package insert.
After administration, close bottle tightly with cap and store syringe in the carton together with the product. Do not disassemble or wash the syringe.
If the cat vomits after consuming any portion of the dose, the cat should not be re-dosed and should be considered as dosed for the day.
Missed Doses
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.
Side Effects
Side effects may include vomiting and mild increases in creatinine and blood pressure. Routine lab monitoring is recommended. Other side effects may occur. If you notice anything unusual, contact your veterinarian.
Drug & Food Interactions
The following drugs can potentially interact with molidustat sodium: aluminum, calcium, magnesium containing products, epoetin alfa, darbepoetin, oral iron, oral zinc, and phosphate binding medications. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 
For oral use in cats only. Keep this drug, including used syringes, out of reach of children. Wash hands immediately after use and/or spillage. Use with caution in cats with a history of seizures and in cats predisposed to thromboembolic disease.  Use has not been evaluated in cats less than 1 year of age.
The syringe included with the product cannot be used to accurately dose cats weighing under 3.4 pounds. As a conditionally approved product, Varenzin™-CA1 should not be used in an off-label manner.
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Symptoms of exposure to molidustat may include the following: gastrointestinal effects (nausea, vomiting, diarrhea), blood and clotting effects (increases in reticulocytes, erythropoietin, and hemoglobin), dizziness, fainting, hypertension, changes in cardiac output and cardiac index, and increases in heart rate.
Symptoms may not occur immediately; therefore, the exposed individual should be monitored. People with known hypersensitivity to molidustat sodium should avoid direct contact with this product and should administer the product with caution.
Women who are pregnant or may become pregnant should administer the product with caution. 
Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.
Adverse Reaction
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco at 888-545-5973 or contact Vetsource customer service at 877-738-4443.
Store between 68°F- 77°F in controlled room temperature. Excursions permitted between 59°F- 86°F. Product is stable for at least 28 days after opening of the container if stored under labeled storage conditions. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.
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Nutritional Info